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5-Hydroxytryptamine G-Protein-Coupled Receptor Family Genes: Key Players in Cancer Prognosis, Immune Regulation, and Therapeutic Response.
Genes (Basel)
November 2024
Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Background: Firstly, 5-hydroxytryptamine G-protein-coupled receptors () are a family of 13 genes associated with cancer progression. Nevertheless, a comprehensive understanding of in cancer remains largely lacking.
Method: We tested the gene expression levels and prognostic values for the in relation to pan-cancer.
The Intricate Interplay: Microbial Metabolites and the Gut-Liver-Brain Axis in Parkinson's Disease.
J Neurosci Res
January 2025
Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Kochi, Kerala, India.
Parkinson's Disease (PD) is a neurodegenerative disorder marked by the depletion of dopaminergic neurons. Recent studies highlight the gut-liver-brain (GLB) axis and its role in PD pathogenesis. The GLB axis forms a dynamic network facilitating bidirectional communication between the gastrointestinal tract, liver, and central nervous system.
View Article and Find Full Text PDFUnveiling the intricacies of irritable bowel syndrome.
World J Gastroenterol
November 2024
Department of Immunology, University of Health Sciences, Hamidiye Medicine Faculty, Istanbul 34668, Türkiye.
Article Synopsis
- Irritable bowel syndrome (IBS) is a complex and chronic condition, making it difficult for both patients and doctors to manage effectively due to its unclear underlying mechanisms.
- Recent research highlights the interaction between the neuroendocrine axis, gut microbiota, and inflammatory responses, suggesting these factors are vital in understanding IBS pathophysiology.
- Dysregulation in the gut-brain axis, influenced by stress and microbiota imbalance, may worsen symptoms, indicating the need for more personalized treatment strategies that consider emotional and gut health factors.
Upstream and downstream pathways of diacylglycerol kinase : Novel phosphatidylinositol turnover-independent signal transduction pathways.
Adv Biol Regul
October 2024
Department of Biosignaling and Radioisotope Experiment, Interdisciplinary Center for Science Research, Organization for Research and Academic Information, Shimane University, Izumo, Japan.
Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to produce phosphatidic acid (PA). Mammalian DGK comprise ten isozymes (α-κ) that regulate a wide variety of physiological and pathological events. Recently, we revealed that DGK isozymes use saturated fatty acid (SFA)/monosaturated fatty acid (MUFA)-containing and docosahexaenoic acid (22:6)-containing DG species, but not phosphatidylinositol (PI) turnover-derived 18:0/20:4-DG.
View Article and Find Full Text PDFThe interplay of serotonin 5-HT1A and 5-HT7 receptors in chronic stress.
J Cell Sci
October 2024
Cellular Neurophysiology, Center of Physiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Serotonin regulates multiple physiological and pathological processes in the brain, including mood and cognition. The serotonin receptors 5-HT1AR (also known as HTR1A) and 5-HT7R (also known as HTR7) have emerged as key players in stress-related disorders, particularly depression. These receptors can form heterodimers, which influence their functions.
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