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Anakinra and hepatotoxicity in pediatric rheumatology: a case series.
Pediatr Rheumatol Online J
October 2023
Pediatric and Young Adult Rheumatology Unit, University Hospital Centre São João, Porto, Portugal.
Background: Anakinra is a recombinant interleukin-1 (IL-1) receptor antagonist used in systemic juvenile idiopathic arthritis (sJIA), refractory Kawasaki disease (KD) and cryopyrin-associated autoinflammatory syndrome (CAPS). Anakinra associated hepatotoxicity, while rare, has been described in several cases in daily practice. In this case series the authors describe three pediatric patients with this side effect in the setting of severe macrophage activation syndrome (MAS) in KD and sJIA.
View Article and Find Full Text PDFCOVID 19-associated chilblain-like acral lesions among children and adolescents: an Italian retrospective, multicenter study.
Ital J Dermatol Venerol
April 2023
Unit of Dermatology, Department of Precision and Regenerative Medicine and Jonian Area, University of Bari, Bari, Italy -
Article Synopsis
- The study investigates the dermatological manifestations of COVID-19 in children, particularly noting the prevalence of chilblain-like lesions among infected and non-infected patients, attributed to a pronounced interferon response in younger individuals.
- Conducted over six months, the research involved 137 patients aged 1 to 18 from 23 Italian dermatological units, who exhibited a variety of skin lesions primarily on the feet.
- Results showed diverse skin symptoms, with many experiencing concomitant systemic symptoms, highlighting the complex interplay of dermatological and respiratory issues related to COVID-19 in children.
Cutaneous Adverse Drug Reactions in a Tertiary Teaching Hospital: A Prospective, Observational Study.
Indian J Dermatol
January 2021
Department of Pharmacology, Dr DY Patil Medical College, Navi Mumbai, Maharashtra, India.
Objective: To describe clinical patterns, identify associated drugs, and perform causality assessment of cutaneous adverse drug reactions.
Materials And Methods: In this prospective, observational study, patients with signs of cutaneous drug reaction from the department of dermatology of a tertiary teaching hospital were included. Patients with viral exanthemas were excluded.
Bullous pemphigoid (BP) appears to be rising in incidence across the Western World, especially in the elderly. Some of the pathogenetic mechanisms involving antigen mimicry and antibody cross-reactivity have been elucidated for cases associated with neurological disease and certain drugs. There have been reports of cutaneous manifestations of Covid-19 (SARS-Cov2 infection) as the pandemic has raged across the world.
View Article and Find Full Text PDFSkin rash following Administration of Apalutamide in Japanese patients with Advanced Prostate Cancer: an integrated analysis of the phase 3 SPARTAN and TITAN studies and a phase 1 open-label study.
BMC Urol
September 2020
Department of Urology, Kindai University Faculty of Medicine, Osaka, Japan.
Background: A higher incidence of apalutamide-related skin rash has been observed in Japanese patients with prostate cancer (PC).
Methods: This integrated analysis of data of Japanese patients from 2 global Phase 3 studies, SPARTAN ( NCT01946204 ; patients with non-metastatic castration-resistant PC [nmCRPC]) and TITAN ( NCT02489318 ; patients with metastatic castration-sensitive PC [mCSPC]), and the Phase 1 study 56021927PCR1008 ( NCT02162836 ; patients with metastatic CRPC [mCRPC]), assessed clinical risk factors of apalutamide-related skin rash as well as the potential correlation with plasma exposure to apalutamide. Kaplan-Meier method was used for time-to-event analyses.
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