AI Article Synopsis
- Thymosin beta4 (Tbeta4) is a key molecule that helps regulate various cellular functions, including cell movement, blood vessel formation, and survival.
- Research supports its potential in clinical trials aimed at tissue protection and regeneration in fields like dermatology and cardiology.
- There’s a specific focus on using Tbeta4 in treating severe heart attacks, particularly in conjunction with coronary intervention techniques.
Article Abstract
Published studies have described a number of physiological properties and cellular functions of thymosin beta4 (Tbeta4), the major G-actin-sequestering molecule in mammalian cells. Those activities include the promotion of cell migration, blood vessel formation, cell survival, stem cell differentiation, the modulation of cytokines, chemokines, and specific proteases, the upregulation of matrix molecules and gene expression, and the downregulation of a major nuclear transcription factor. Such properties have provided the scientific rationale for a number of ongoing and planned dermal, corneal, cardiac clinical trials evaluating the tissue protective, regenerative and repair potential of Tbeta4, and direction for future clinical applications in the treatment of diseases of the central nervous system, lung inflammatory disease, and sepsis. A special emphasis is placed on the development of Tbeta4 in the treatment of patients with ST elevation myocardial infarction in combination with percutaneous coronary intervention.
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| http://dx.doi.org/10.1111/j.1749-6632.2010.05492.x | DOI Listing |
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