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Synthesis, characterization and drug release of biocompatible/biodegradable non-toxic poly(urethane urea)s based on poly(epsilon-caprolactone)s and lysine-based diisocyanate. | LitMetric
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Synthesis, characterization and drug release of biocompatible/biodegradable non-toxic poly(urethane urea)s based on poly(epsilon-caprolactone)s and lysine-based diisocyanate.

Thatiparti Thimma Reddy Arihiro Kano Atsushi Maruyama Atsushi Takahara

J Biomater Sci Polym Ed

Institute for Materials Chemistry and Engineering, Kyushu University, Nishi-ku, Fukuoka 812-0395, Japan.

Published: November 2010

Segmented poly(urethane urea)s (SPUUs) based on aliphatic diisocyanato (2,6-diisocyanato methyl caproate (lysine-based diisocyanate, LDI)), poly(epsilon-caprolactone diol)s (PCLs) with molecular weights 530, 1250 and 2000, and 1,4-butanediamine were synthesized in absence of catalyst. The resulting SPUUs, with different soft segment length, were characterized by suitable analytical techniques. The synthesized SPUUs had high molecular weights, low glass-transition temperatures (

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http://dx.doi.org/10.1163/092050609X12518804794785DOI Listing

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