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Updated Mini-Review on Polychlorinated Diphenyl Ethers (PCDEs) in Food: Levels and Dietary Intake.
J Food Prot
January 2025
Universitat Rovira i Virgili Laboratory of Toxicology and Environmental Health, School of Medicine, 43201, Reus, Catalonia, Spain. Electronic address:
Polychlorinated diphenyl ethers (PCDEs) are a class of chlorinated aromatic compounds with structural similarities to polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs). Due to their physicochemical properties, PCDEs are highly resistant to degradation and tend to accumulate in soils, sediments, and aquatic organisms, making them capable of entering and persisting in the food chain. As with other persistent organic pollutants (POPs), diet represents the primary route of human exposure to PCDEs.
View Article and Find Full Text PDFIntergenerational transfer of micro(nano)plastics in different organisms.
J Hazard Mater
January 2025
Stockbridge School of Agriculture, University of Massachusetts, Amherst, MA 01003, USA.
Micro(nano)plastics (MNPs), widely distributed in the environment, can be ingested and accumulated by various organisms. Recently, the transgenerational transport of MNPs from parental organisms to their offspring has attracted increasing attention. In this review, we summarize the patterns, specific pathways, and related mechanisms of intergenerational transfer of MNPs in plants, non-mammals (zooplankton and fish) and mammals.
View Article and Find Full Text PDFREACH assessment of humans exposed to chemicals indirectly via the environment: screening modeling in EUSES versus state of the science.
Integr Environ Assess Manag
January 2025
Henkel AG & Co KGaA, Düsseldorf, Germany.
The assessment of humans indirectly exposed to chemicals via the environment (HvE) is an assessment element of the Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH) regulation. The European Union System for the Evaluation of Substances (EUSES) is the default screening tool, aimed at prioritizing chemicals for further refinement/higher tier assessment. This review summarizes the approach used in EUSES, evaluates the state of the science in human exposure modeling via the environment, and identifies areas for further research to strengthen the confidence and applicability of EUSES for assessing HvE.
View Article and Find Full Text PDFBCOR abnormalities in endometrial stromal sarcoma.
Gynecol Oncol Rep
February 2025
Department of Obstetrics and Gynaecology, Faculty of Medicine, King Abdulaziz University, Rabigh, Saudi Arabia.
Endometrial stromal tumors (ESTs) are uncommon mesenchymal tumors of the reproductive system associated with heterogeneous histomolecular features. According to the World Health Organization (WHO), ESTs are classified into benign endometrial stromal nodules (BESN) and endometrial stromal sarcomas (ESSs), which are further divided into low-grade and high-grade subtypes. High-grade ESS is frequently associated with YWHAE-NUTM2 gene fusions, while a newly recognized subtype with BCOR rearrangements, including fusions, alterations, and internal tandem duplications (ITDs), has recently been incorporated into the molecular classification of ESS.
View Article and Find Full Text PDFPyriproxyfen, villain or good guy? A brief review.
Arch Endocrinol Metab
January 2025
Universidade Federal do Rio de Janeiro Instituto de Ciências Biomédicas Laboratório de Endocrinologia Experimental Rio de JaneiroRJ Brasil Laboratório de Endocrinologia Experimental (LEEx), Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Pyriproxyfen (PPF) acts as a juvenile growth regulator, interfering with normal metamorphosis and blocking the development of insects into adulthood. Although the World Health Organization (WHO) considers the use of PPF at a concentration of 0.01 mg/L as unlikely to pose health risks, recent studies have unveiled potential risks associated with PPF exposure to non-target organisms.
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