In the development of structural equation models (SEMs), observed variables are usually assumed to be normally distributed. However, this assumption is likely to be violated in many practical researches. As the non-normality of observed variables in an SEM can be obtained from either non-normal latent variables or non-normal residuals or both, semiparametric modeling with unknown distribution of latent variables or unknown distribution of residuals is needed. In this article, we find that an SEM becomes nonidentifiable when both the latent variable distribution and the residual distribution are unknown. Hence, it is impossible to estimate reliably both the latent variable distribution and the residual distribution without parametric assumptions on one or the other. We also find that the residuals in the measurement equation are more sensitive to the normality assumption than the latent variables, and the negative impact on the estimation of parameters and distributions due to the non-normality of residuals is more serious. Therefore, when there is no prior knowledge about parametric distributions for either the latent variables or the residuals, we recommend making parametric assumption on latent variables, and modeling residuals nonparametrically. We propose a semiparametric Bayesian approach using the truncated Dirichlet process with a stick breaking prior to tackle the non-normality of residuals in the measurement equation. Simulation studies and a real data analysis demonstrate our findings, and reveal the empirical performance of the proposed methodology. A free WinBUGS code to perform the analysis is available in Supporting Information.
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http://dx.doi.org/10.1002/bimj.200900135 | DOI Listing |
Neuro Endocrinol Lett
December 2024
Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Background: Severe or recurring major depression is associated with increased adverse childhood experiences (ACEs), heightened atherogenicity, and immune-linked neurotoxicity (INT). Nevertheless, the interconnections among these variables in outpatient major depression (OMDD) have yet to be determined. We aim to determine the correlations among INT, atherogenicity, and ACEs in OMDD patients compared to normal controls.
View Article and Find Full Text PDFBioinformatics
December 2024
School of Computer Science and Engineering, The Hebrew University of Jerusalem.
Motivation: Non-negative Matrix Factorization (NMF) is a powerful tool often applied to genomic data, to identify non-negative latent components that constitute linearly mixed samples. It is useful when the observed signal combines contributions from multiple sources, such as cell types in bulk measurements of heterogeneous tissue. NMF accounts for two types of variation between samples-disparities in the proportions of sources and observation noise.
View Article and Find Full Text PDFComput Biol Med
December 2024
Shandong Technology and Business University, 191 Binhai Middle Road, Yantai, Shandong, China.
The classification of Doppler ultrasound images plays an important role in the diagnosis of pregnancy. However, it is a challenging problem that suffers from a variable length of these images with a dimension gap between them. In this study, we propose a latent representation weights learning method (LRWL) for pregnancy prediction using Doppler ultrasound images.
View Article and Find Full Text PDFIndian J Ophthalmol
December 2024
Department of Ophthalmology, Yenepoya Deemed University, Karnataka, India.
Background/aims: India's linguistic and cultural diversity necessitates a region-specific validated Visual Functioning Questionnaire. The objective of this study was to translate the Indian Vision Function Questionnaire-33 (IND-VFQ-33) into the Kannada language and test its psychometric properties, underlying factor structure, and model fit.
Methods: A cross-sectional study was conducted among 330 participants, and basic psychometric properties (reliability, convergent, discriminant, construct validity, responsiveness, etc.
Int J Nurs Knowl
December 2024
Department of Nursing, Federal University of Ceará, Fortaleza, Brazil.
Purpose: To evaluate the accuracy of clinical indicators and etiological factors associated with the nursing diagnosis of excessive sedentary behavior among university students.
Method: This study employed a cross-sectional diagnostic accuracy design. The sample comprised 108 students from a Brazilian public university.
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