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The relevance of combined testing of cerebrospinal fluid glial fibrillary acidic protein and ubiquitin C-terminal hydrolase L1 in multiple sclerosis and peripheral neuropathy.
Neurol Sci
November 2024
Department of Primary Health Care, Medical School University of Pecs, Pecs, Hungary.
Introduction: This study investigates the significance of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCHL-1) in cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and peripheral neuropathy (PN).
Methods: We included 41 MS patients, 35 PN patients, and 36 controls across 5 sites. MS patient data included lesion counts, disease activity, albumin quotient, and Expanded Disability Status Scale (EDSS) scores.
Mucinous adenocarcinoma in kidneys with developmental anomalies - a report of two cases.
BMC Urol
November 2024
Department of Urology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Article Synopsis
- Primary mucinous adenocarcinomas of the kidney are rare and their origins are unclear, with theories including chronic irritation and kidney maldevelopment.
- Two cases are presented: one involving a 50-year-old male with a duplex collecting system who had invasive mucinous carcinoma, and another case with a 53-year-old male who had a horseshoe kidney and recurrent mucinous adenocarcinoma after previous surgery.
- Both cases highlight the association between mucinous adenocarcinomas and kidney anomalies, emphasizing the importance of histopathology for diagnosis.
Primary Orbital Conjunctival Cyst Associated With the Inferior Rectus Muscle.
Cureus
October 2024
Oculoplastic, Orbital and Lacrimal Surgery, Aichi Medical University Hospital, Aichi, JPN.
Primary simple conjunctival cysts are congenital, non-neoplastic, fluid-filled lesions lined by non-keratinizing squamous epithelium without dermal appendages. They are usually located in the anterior superonasal or superotemporal orbit and are typically managed with complete surgical excision. A 69-year-old woman presented with a 10-month history of diplopia and a 2-week history of right lower eyelid swelling.
View Article and Find Full Text PDFCauses of missed MRI diagnosis of radiotherapy-induced temporal lobe injury in nasopharyngeal carcinoma.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2024
Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008.
Objectives: Radiotherapy is the primary treatment for nasopharyngeal carcinoma, but it frequently leads to radiotherapy-induced temporal lobe injury (RTLI). Magnetic resonance imaging (MRI) is the main diagnostic method for RTLI after radiotherapy for nasopharyngeal carcinoma, but it is prone to missed diagnoses. This study aims to investigate the causes of missed diagnoses of RTLI in nasopharyngeal carcinoma patients undergoing MRI after radiotherapy.
View Article and Find Full Text PDFGlioma Grade and Molecular Markers: Comparing Machine-Learning Approaches Using VASARI (Visually AcceSAble Rembrandt Images) Radiological Assessment.
Cureus
July 2024
Department of Surgery, Faculty of Medicine, Public Health, and Nursing, Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, IDN.
Objectives: This study aimed to leverage Visually AcceSAble Rembrandt Images (VASARI) radiological features, extracted from magnetic resonance imaging (MRI) scans, and machine-learning techniques to predict glioma grade, isocitrate dehydrogenase (IDH) mutation status, and O6-methylguanine-DNA methyltransferase (MGMT) methylation.
Methodology: A retrospective evaluation was undertaken, analyzing MRI and molecular data from 107 glioma patients treated at a tertiary hospital. Patients underwent MRI scans using established protocols and were evaluated based on VASARI criteria.
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