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Performance of deep learning model and radiomics model for preoperative prediction of spread through air spaces in the surgically resected lung adenocarcinoma: a two-center comparative study.
Transl Lung Cancer Res
December 2024
Department of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Background: Spread through air spaces (STAS) in lung adenocarcinoma (LUAD) is a distinct pattern of intrapulmonary metastasis where tumor cells disseminate within the pulmonary parenchyma beyond the primary tumor margins. This phenomenon was officially included in the World Health Organization (WHO)'s classification of lung tumors in 2015. STAS is characterized by the spread of tumor cells in three forms: single cells, micropapillary clusters, and solid nests.
View Article and Find Full Text PDFConsensus Recommendations for the Management of Neurosarcoidosis: A Delphi Survey of Experts Across the United States.
Neurol Clin Pract
April 2025
Department of Neurology, New York University Langone Health.
Background And Objectives: Neurosarcoidosis poses a diagnostic and management challenge due to its rarity, phenotypic variability, and lack of randomized controlled studies to guide treatment selection. Recommendations for management based on expert opinion are useful in clinical practice and provide a framework for designing prospective studies.
Methods: In this Delphi survey study, specialists with experience in managing patients with neurosarcoidosis were invited to anonymously complete 2 surveys about key elements of evaluation, diagnosis, treatment, monitoring, and long-term management of neurosarcoidosis.
Vascular flow alteration is a dominant pattern of liver pathology in patients with orthotopic lung transplants: a retrospective observational study.
Histopathology
January 2025
Department of Pathology, Duke University Health System, Durham, North Carolina, USA.
Aims: The number of orthotopic lung transplants (OLT) has skyrocketed since the 1960s, generating an ever-increasing cohort of post-OLT patients. Many challenges exist in the post-OLT timeframe, including donor graft dysfunction, infection, malignancy, and immunosuppression-related conditions. A rather elusive topic in the posttransplant setting remains the impact of the underlying disease process and donor lungs on other organ systems and the complications arising from the complex physiologic interactions.
View Article and Find Full Text PDFClinicopathological and prognostic significance of exosomal PD-L1 in cancer therapy.
Biomark Med
January 2025
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
Aim: The exosomal programmed death ligand-1(exoPD-L1) has recently become a topic of interest in the field of oncology. But the prognostic role of exoPD-L1 in cancer patients is inconsistent across previous studies. Therefore, a quantitative meta-analysis was performed to evaluate the prognostic and clinicopathological value of exoPD-L1 in cancer patients.
View Article and Find Full Text PDFEvolving Paradigms in the Treatment of Oligometastatic Pancreatic Ductal Adenocarcinoma.
J Gastrointest Cancer
January 2025
Department of Gastrointestinal Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Multiple randomized trials have suggested that the addition of comprehensive metastasis-directed therapy to best systemic therapy improves disease control and survival among patients with oligometastatic disease, even for histologies with a high propensity for rapid spread. Here, we review the growing literature supporting the oligometastatic paradigm in pancreatic ductal adenocarcinoma. We summarize key details from nascent institutional series and reflect on the recently reported phase II randomized EXTEND trial.
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