Purpose: The aim of this study was to develop a computerized method to quantify the coincidence between portal image graticules and radiation field centers or radiation isocenter. Three types of graticules were included in this study: Megavoltage (MV) mechanical graticule, MV electronic portal imaging device digital graticule, and kilovoltage (kV) on-board imaging digital graticule.
Methods: A metal ball bearing (BB) was imaged with MV and kV x-ray beams in a procedure similar to a Winston-Lutz test. The radiation fields, graticules, and BB were localized in eight portal images using Hough transform-based computer algorithms. The center of the BB served as a static reference point in the 3D space so that the distances between the graticule centers and the radiation field centers were calculated. The radiation isocenter was determined from the radiation field centers at different gantry angles.
Results: Misalignments of MV and kV portal imaging graticules varied with the gantry or x-ray source angle as a result of mechanical imperfections of the linear accelerator and its imaging system. While the three graticules in this study were aligned to the radiation field centers and the radiation isocenter within 2.0 mm, misalignments of 1.5-2.0 mm were found at certain gantry angles. These misalignments were highly reproducible with the gantry rotation.
Conclusions: A simple method was developed to quantify the alignments of portal image graticules directly against the radiation field centers or the radiation isocenter. The advantage of this method is that it does not require the BB to be placed exactly at the radiation isocenter through a precalibrated surrogating device such as room lasers or light field crosshairs. The present method is useful for radiation therapy modalities that require high-precision portal imaging such as image-guided stereotactic radiotherapy.
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http://dx.doi.org/10.1118/1.3397452 | DOI Listing |
Med Phys
January 2025
OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany.
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View Article and Find Full Text PDFMed Phys
January 2025
Department of Engineering Physics, Tsinghua University, Beijing, China.
Background: X-ray grating-based dark-field imaging can sense the small angle scattering caused by object's micro-structures. This technique is sensitive to the porous microstructure of lung alveoli and has the potential to detect lung diseases at an early stage. Up to now, a human-scale dark-field CT (DF-CT) prototype has been built for lung imaging.
View Article and Find Full Text PDFSci Rep
January 2025
College of Engineering, Applied Science University (ASU), Manama, Kingdom of Bahrain.
This paper presents an in-depth analytical investigation into the time-dependent flow of a Casson hybrid nanofluid over a radially stretching sheet. The study introduces the effects of magnetic fields and thermal radiation, along with velocity and thermal slip, to model real-world systems for enhancing heat transfer in critical industrial applications. The hybrid nanofluid consists of three nanoparticles-Copper and Graphene Oxide-suspended in Kerosene Oil, selected for their stable and superior thermal properties.
View Article and Find Full Text PDFEndocrine
January 2025
Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
The word "cancer" evokes myriad emotions, ranging from fear and despair to hope and determination. Cancer is aptly defined as a complex and multifaceted group of diseases that has unapologetically led to the loss of countless lives and affected innumerable families across the globe. The battle with cancer is not only a physical battle, but also an emotional, as well as a psychological skirmish for patients and for their loved ones.
View Article and Find Full Text PDFJ Mater Sci Mater Med
January 2025
Department of Nuclear Medicine, Chongqing University Cancer Hospital, No. 181 HanYu St, Shapingba District, Chongqing, 400030, PR China.
Human hair keratin, a natural protein derived from human hair, has emerged prominently in the field of wound repair, showcasing its unique regenerative capabilities and extensive application potential. However, it is a challenge for the keratin to efficiently therapy the impaired wound healing, such as combined radiation-wound injury. Here, we report a keratin/chitosan (KRT/CS) film for skin repair of chronic wounds in in rats with combined radiation-wound injury.
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