The clinical and pathological characteristics of a rare granular cell tumor that developed in the vulva (4 cases) and the breast (1 case) offive women aged 35-52 years are reported. The differential diagnosis from skin carcinomas, melanoma and various soft tissue tumors is emphasized.
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Microbial fuel cells to monitor natural attenuation around groundwater plumes.
Environ Sci Pollut Res Int
January 2025
School of Natural and Built Environment, Queen's University Belfast, Belfast, Northern Ireland, BT7 1NN, UK.
This research presents a straightforward and economically efficient design for a microbial fuel cell (MFC) that can be conveniently integrated into a borehole to monitor natural attenuation in groundwater. The design employs conventional, transparent, and reusable PVC bailers with graphite tape and granular activated carbon to create high surface area electrodes. These electrodes are connected across redox environments in nested boreholes through a wire and variable resistor setup.
View Article and Find Full Text PDFHigh-alcohol-producing Klebsiella pneumoniae aggravates lung injury by affecting neutrophils and the airway epithelium.
Cell Rep Med
December 2024
Capital Institute of Pediatrics, Beijing 100020, China. Electronic address:
We have previously reported that high-alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) in the gut can cause endo-alcoholic fatty liver disease. Here, we discover that 91.2% of Kpn isolates from pulmonary disease samples also produce excess ethanol, which may be associated with respiratory disease severity.
View Article and Find Full Text PDFBackground: Directed by the enzyme pair PINK1 and PRKN, mitophagy is a crucial mitochondrial quality control mechanism that selectively decorates damaged mitochondria with phosphorylated ubiquitin (pS65-Ub), facilitating their lysosomal degradation. The dynamic pS65-Ub signal accumulates upon enhanced activation from increased mitochondrial damage or upon reduced autophagic-lysosomal flux. Previous studies including ours demonstrated altered mitophagy and elevated pS65-Ub levels in Parkinson's and Alzheimer's disease brains that also independently associated with α-synuclein, tau, or amyloid pathology.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of Ibadan, Ibadan, Oyo, Nigeria.
Background: The brain is a potential target for aluminium toxicity as it induces oxidative stress, strategies, rich in polyphenolic compound, containing flavonoid and possessing antioxidant property, found in natural plant products, to attenuate aluminium-induced impairments could provide a potential therapeutic intervention and protection for aluminium neurotoxicity.
Method: Forty adult rats weighing between 160 - 165g was used. The rats were divided into four groups (n = 10).
Multicentric Reticulohistiocytosis.
Skinmed
January 2025
Department of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, PA;
A Caucasian woman in her twenties having asymptomatic papules on the hands for the past 6 months was referred by rheumatology for a skin biopsy. The patient had presented to rheumatologist for arthralgia. On physical examination, multiple, dull red, 2-5-mm papules were observed on her dorsal fingers, with most in the periungual regions.
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