AI Article Synopsis
- - We conducted a genome-wide association study for generalized vitiligo focusing on the Chinese Han population, involving over 1,100 cases and almost 1,500 controls, followed by a larger replication study in different Chinese populations.
- - Two significant genetic markers in the major histocompatibility complex (MHC) region were identified, one associated with increased risk (rs11966200) and another potentially protective (rs9468925) related to specific HLA alleles.
- - Additionally, we discovered a new risk locus at 6q27 (rs2236313) linked to three genes, contributing to a better understanding of the genetic factors involved in vitiligo.
Article Abstract
We conducted a genome-wide association study of generalized vitiligo in the Chinese Han population by genotyping 1,117 cases and 1,429 controls. The 34 most promising SNPs were carried forward for replication in samples from individuals of the Chinese Han (5,910 cases and 9,916 controls) and Chinese Uygur (713 cases and 824 controls) populations. We identified two independent association signals within the major histocompatibility complex (MHC) region (rs11966200, Pcombined=1.48x10(-48), OR=1.90; rs9468925, Pcombined=2.21x10(-33), OR=0.74). Further analyses suggested that the strong association at rs11966200 might reflect the reported association of the HLA-A*3001, HLA-B*1302, HLA-C*0602 and HLA-DRB1*0701 alleles and that the association at rs9468925 might represent a previously unknown HLA susceptibility allele. We also identified one previously undescribed risk locus at 6q27 (rs2236313, Pcombined=9.72x10(-17), OR=1.20), which contains three genes: RNASET2, FGFR1OP and CCR6. Our study provides new insights into the genetic basis of vitiligo.
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| http://dx.doi.org/10.1038/ng.603 | DOI Listing |
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