Protocol for 18F-FDG quantification in PET-CT whole-body exams.

Cell Mol Biol (Noisy-le-grand)

Instituto de Radioproteção e Dosimetria, CNEN, Rio de Janeiro, Brazil.

Published: May 2010

The aim of the present work is to propose a protocol for quantification of (18)F-FDG activities at organ level through whole body exams with Positron Emission Tomography. They were selected patients with normal uptake or a single tumor. In the period 2004-2005, 745 patients were studied. Among then, it was selected 97 adults for the normal uptake control group. The main studies were: intestine; colon, rectum, lung, lymphoma and melanoma, liver, esophagus, gonads and breasts. For "prospective screening", it were selected 20 patients with the identical physical characteristics of the control group. For internal dosimetry, the main organs should be elected according the kinetics of (18)F-FDG, either considering normal uptake or pathologies. Absorbed doses due to Computed Tomography and F-FDG uptake were estimated. Comparisons between internal and external exposures, for the same organ, point out higher doses due to external irradiation, except for bladder and kidneys. For individual dose estimation, parameters such the effective half-life should be known and this information may be achieved by an adaptation of the routine protocol.

Download full-text PDF

Source

Publication Analysis

Top Keywords

normal uptake
12
selected patients
8
control group
8
protocol 18f-fdg
4
18f-fdg quantification
4
quantification pet-ct
4
pet-ct whole-body
4
whole-body exams
4
exams aim
4
aim work
4

Similar Publications

Precipitation is an important factor influencing the date of foliar senescence, which in turn affects carbon uptake of terrestrial ecosystems. However, the temporal patterns of precipitation frequency and its impact on foliar senescence date remain largely unknown. Using both long-term carbon flux data and satellite observations across the Northern Hemisphere, we show that, after excluding impacts from of temperature, radiation and total precipitation by partial correlation analysis, declining precipitation frequency may drive earlier foliar senescence date from 1982 to 2022.

View Article and Find Full Text PDF

Physiological Fatty Acid-Stimulated Insulin Secretion and Redox Signaling Lipotoxicity.

Antioxid Redox Signal

January 2025

Department of Mitochondrial Physiology, No.75, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.

Type 2 diabetes as a world-wide epidemic is characterized by the insulin resistance concomitant to a gradual impairment of β-cell mass and function (prominently declining insulin secretion) with dysregulated fatty acids (FAs) and lipids, all involved in multiple pathological development. Recently, redox signaling was recognized to be essential for insulin secretion stimulated with glucose (GSIS), branched-chain keto-acids, and FAs. FA-stimulated insulin secretion (FASIS) is a normal physiological event upon postprandial incoming chylomicrons.

View Article and Find Full Text PDF

We performed all-atom and coarse-grained simulations of lipid bilayer mixtures of the unsaturated lipid DOPC, with saturated lipids having the same 18-carbon acyl tails and different headgroups, to understand their mechanical properties. The secondary lipids were DSPG, DSPA, DSPS, DSPC, and DSPE. The DOPC:DSPG system with 65:35 molar ratio was the softest, with area compressibility modulus ∼ 22% smaller than the pure DOPC value.

View Article and Find Full Text PDF

Despite advances in treatment, the prognosis of osteosarcoma (OS) patients is unsatisfactory, and searching for possible targets is substantial. Fibroblast growth factor inducible type 14 (FN14), a plasma membrane protein, is involved in wound healing, angiogenesis, proliferation, apoptosis, and inflammation. However, its implication in OS development and progression has not been completely characterized.

View Article and Find Full Text PDF

Synthesis of pillar-layered metal-organic frameworks with variable backbones through sequence control.

Nat Chem

January 2025

Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, State Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan, China.

The properties and functions of metal-organic frameworks (MOFs) can be tailored by tuning their structure, including their shape, porosity and topology. However, the design and synthesis of complex structures in a predictable manner remains challenging. Here we report the preparation of a series of isomeric pillar-layered MOFs, and we show that their three-dimensional topology can be controlled by altering the layer stacking.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!