Objective: To report topographic matching of selected donor sites and donor core sizes for congruous reconstruction of the weight-bearing aspect of the femoral condyles in dogs for autologous osteochondral transplantation (AOT) using computer simulation.
Study Design: Computer simulation.
Sample Population: Computed tomographic scans of the distal aspect of 1 femur from each of 6 mature dogs (>20 kg).
Methods: Three-dimensional surface models of the distal femora were constructed for virtual AOT. Different donor sites (n=15) within and outside the femoropatellar joint and 5 transplant sizes (diameters 3.5, 4.5, 6.0, 8.0, and 10.0 mm) were analyzed with respect to their topographic match with the articular surface of both femoral condyles.
Results: Transplants from the proximal abaxial aspect of the medial condyle and from the abaxial aspects of the medial and lateral trochlear ridges were the best topographic match. Mismatch increased linearly with increasing core diameter. Small core diameters (3.5 mm, 4.5 mm) from within the femoropatellar joint allowed restoration of surface contour at both femoral condyles similar to large core diameters (6 mm, 8 mm) from outside the femoropatellar joint.
Conclusions: Based on this computer simulation, large core diameters should only be harvested from convex donor sites outside the femoropatellar joint, whereas transplants from the concave, axial aspects of the trochlear ridges may result in similar topographic match provided they are of small diameter.
Clinical Relevance: The abaxial aspect of the medial trochlear ridge and the proximal aspect of the medial femoral condyle appear to be the preferred AOT donor sites.
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http://dx.doi.org/10.1111/j.1532-950X.2010.00671.x | DOI Listing |
J Am Chem Soc
January 2025
Research Center for Solar Energy Chemistry and Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, Toyonaka 560-8531, Japan.
Photocatalytic transformation of nitrate (NO) in wastewater into ammonia (NH) is a challenge in the detoxification and recycling of limited nitrogen resources. In particular, previously reported photocatalysts cannot promote the reaction using water as an electron donor. Herein, we report that copper-doped titanium dioxide (Cu-TiO) powders, prepared via the sol-gel method and subsequent calcination, promote NO-to-NH reduction in water.
View Article and Find Full Text PDFMini Rev Med Chem
January 2025
Drug Discovery and Research Laboratory, Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur 495009, Chhattisgarh, India.
Hydantoin, a five-membered heterocyclic scaffold, is regarded as a crucial scaffold in medicinal chemistry. Hydantoins have been useful in synthesizing medicines like nilutamide, enzalutamide, and apalutamide. Thiohydantoin and selenohydantoin have been discovered as two separate types of hydantoin.
View Article and Find Full Text PDFNat Commun
January 2025
School of Nuclear Science and Technology, Key Laboratory of Precision and Intelligent Chemistry, National Synchrotron Radiation Laboratory, School of Chemistry and Materials Science, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui, PR China.
Solar-driven, selective biomass hydrogenation is recognized as a promising route to renewable chemicals production, but remains challenging. Here, we report a TiO supported Cu single-atom catalyst with a four-coordinated Cu-O structure, which can be universally applied for solar-driven production of various renewable chemicals from lignocellulosic biomass-derived platform molecules with good yields using green methanol as a hydrogen donor, to address this challenge. It is significant that the biomass upgrading driven by natural sunlight on a gram scale demonstrates the great practical potential.
View Article and Find Full Text PDFInorg Chem
January 2025
School of Materials Science and Engineering, Hainan University, Haikou 570228, China.
Hydrogen-bonded organic frameworks (HOFs) are under fast development in broad applications but have not been well explored for chemiresistive gas sensing yet primarily due to insufficient active sites. Herein, a new porphyrin-based HOF-199 is constructed by OH···O hydrogen bonds featuring layered networks and rich free oxygen (O) atoms, which is further exfoliated into few-layer nonosheets with more dangling O sites through an ultrasound-assisted liquid exfoliation method (namely L-HOF-199). Benefiting from rich electron-donor sites, L-HOF-199 demonstrates exceptional NO sensing properties under ambient conditions, achieving a remarkable 3.
View Article and Find Full Text PDFCornea
January 2025
Department of Ophthalmology and Visual Sciences, Case Western Reserve University School of Medicine, University Hospitals Eye Institute, Cleveland, OH.
Purpose: Describe aims, methods, characteristics of donors, donor corneas and recipients, and potential impact of the Diabetes Endothelial Keratoplasty Study (DEKS).
Methods: The DEKS is a randomized, clinical trial to assess graft success and endothelial cell density (ECD) 1 year after Descemet membrane endothelial keratoplasty (DMEK) using corneas from donors with versus without diabetes in a 1:2 minimization assignment. Diabetes severity in the donor is assessed by medical history, postmortem HbA1c, and donor skin advanced glycation end-products and oxidation markers.
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