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Genomic Insights of Multidrug-Resistant Enterococcus faecalis and Acinetobacter baumannii Isolated from a Sepsis Patient with Pauci-Immune Crescentic Glomerulonephritis, India.
Curr Microbiol
November 2024
Symbiosis School of Biological Sciences (SSBS), Symbiosis International (Deemed University) (SIU), Lavale, Pune, Maharashtra, 412115, India.
Article Synopsis
- * A recent genomic study identified extensively drug-resistant strains of these bacteria from a blood sample of a patient with a specific kidney condition (pauci-immune crescentic glomerulonephritis), utilizing whole-genome sequencing to analyze their characteristics.
- * The analysis revealed distinct genome sizes and features, including multiple virulence factors and antimicrobial resistance mechanisms, emphasizing the need to understand these polymicrobial infections for better treatment strategies.
The Evolving Global Epidemiology of Human Melioidosis: A Narrative Review.
Pathogens
October 2024
Harvard Medical School, Boston, MA 02115, USA.
Endemic in over 45 countries globally, recent reports of locally acquired melioidosis in novel geographical areas, such as the Southern US, have highlighted the expanding geographical range of . Climate change and severe weather events have been linked to an increase in cases of melioidosis, which follows environmental exposure to the bacterium. Healthcare professionals should be aware of the possibility of the disease, with its diverse and often delayed presentations, even in areas not previously known to have risk.
View Article and Find Full Text PDFNosocomial Transmission of Necrotizing Fasciitis: A Molecular Characterization of Group A Streptococcal DNases in Clinical Virulence.
Microorganisms
October 2024
Molecular Bacteriology, European Plotkin Institute for Vaccinology (EPIV), Université Libre de Bruxelles, 1070 Bruxelles, Belgium.
, or Group A (GAS), is responsible for over 500,000 deaths per year. Approximately 15% of these deaths are caused by necrotizing soft-tissue infections. In 2008, we isolated an M5 GAS, named the LO1 strain, responsible for the nosocomial transmission of necrotizing fasciitis between a baby and a nurse in Belgium.
View Article and Find Full Text PDFClostridium Perfringens as a Rare Cause of Spontaneous Bacterial Peritonitis.
Cureus
September 2024
Internal Medicine, Grand Strand Medical Center, Myrtle Beach, USA.
Article Synopsis
- Spontaneous bacterial peritonitis (SBP) is a severe condition that can occur in patients with liver cirrhosis and fluid buildup (ascites), and this case report reveals an uncommon cause of SBP from loculated ascites.
- The infection was caused by a rare bacterium, which can occur despite SBP usually being linked to more common pathogens.
- The patient showed a positive response to treatment, with a significant improvement in symptoms and a resolution of bacterial growth in follow-up fluid cultures.
Early identification of the nosocomial spread of vancomycin-resistant by Fourier-transform infrared spectroscopy and performance comparison with PFGE and WGS.
Emerg Microbes Infect
December 2024
Department of Microbiology, Biomedical Diagnostic Center (CDB) and ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Early detection of disseminating vancomycin-resistant (VREfm) in ICU wards is crucial for outbreak identification and the implementation of prompt infection control measures. Genotypic methods like pulsed-field gel electrophoresis (PFGE) and whole-genome sequencing (WGS) are costly and time-consuming, hindering rapid response due to batch dependency. Fourier-transform infrared spectroscopy (FT-IR) offers the potential for real-time outbreak detection and reliable strain typing.
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