Background: A Local Health Unit in the Umbria Region of Italy carried out environmental investigations to estimate exposure to respirable particles among workers in a number of companies belonging to the ceramics and brick industries manufacturing categories.
Objectives: The purpose of this paper was to estimate the degree of agreement of two sampling methods, Dorr-Oliver and GS3 selectors. Both selectors are deemed to comply with the respirable particles sampling reported in European Standard EN 481/1993.
Methods: For each worker, respirable particles and the quartz contained therein were collected using Dorr-Oliver and GS3 selectors simultaneously, so that quartz exposure was also measured.
Conclusions: The comparison between the two series of airborne concentrations of respirable particles (collected with the two selectors), showed statistically significant differences (p < 0.05 with Student's t test). Moreover, Pearson's coefficient showed a low correlation between the two series of data. A similar conclusion was obtained analysing quartz airborne concentrations. The results seem to confirm that the two sampling methods possess a different capture power ofparticles as a function of their size.
Download full-text PDF |
Source |
---|
AAPS J
January 2025
Laboratory of Pharmaceutical Technology and Biopharmacy, CIRM, University of Liège, 4000, Liège, Belgium.
In addition to the known therapeutic indications for cannabidiol, its administration by inhalation appears to be of great interest. Indeed, there is evidence of cannabidiol's efficacy in several physiological pathways, suggesting its potential for a wide range of applications for both local and systemic pulmonary administration like cancers. Significant advances in pulmonary drug delivery have led to innovative strategies to address the challenges of increasing the respirable fraction of drugs and standardizing inhalable products.
View Article and Find Full Text PDFSmall
January 2025
BASF SE, Dept. Analytical & Material Science, 67056, Ludwigshafen, Germany.
Assessing the inhalation hazard of microplastics is important but necessitates sufficient quantity of microplastics that are representative and respirable (<4 µm). Common plastics are not typically manufactured in such small sizes. Here, solvent precipitation is used to produce respirable test materials from thermoplastics polyurethane (TPU), polyamide (PA-6), polyethylene terephthalate (PET), and low-density polyethylene (LDPE).
View Article and Find Full Text PDFPharmaceutics
December 2024
Department of Pharmaceutical Sciences, College of Pharmacy, QU Health Sector, Qatar University, Doha 2713, Qatar.
Background/objectives: This study aimed to fabricate, optimize, and characterize nanostructured lipid carriers (NLCs) loaded with trans-resveratrol (TRES) as an anti-cancer drug for pulmonary drug delivery using medical nebulizers.
Methods: Novel TRES-NLC formulations (F1-F24) were prepared via hot, high-pressure homogenization. One solid lipid (Dynasan 116) was combined with four liquid lipids (Capryol 90, Lauroglycol 90, Miglyol 810, and Tributyrin) in three different ratios (10:90, 50:50, and 90:10 /), with a surfactant (Tween 80) in two different concentrations (0.
Pharmaceutics
December 2024
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK.
Background: Spray drying, whilst a popularly employed technique for powder formulations, has limited applications for large-scale proliposome manufacture.
Objectives: Thus, the aim of this study was to investigate spray drying parameters, such as inlet temperature (80, 120, 160, and 200 °C), airflow rate (357, 473, and 601 L/h) and pump feed rate (5, 15, and 25%), for individual carbohydrate carriers (trehalose, lactose monohydrate (LMH), and mannitol) for 24 spray-dried (SD) formulations (F1-F24).
Methods: Following optimization, the SD parameters were trialed on proliposome formulations based on the same carriers and named as spray-dried proliposome (SDP) formulations.
ACS Omega
December 2024
Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH) Centers for Disease Control and Prevention (CDC),1090 Tusculum Ave,Cincinnati, Ohio 45226, United States.
Inhalation exposure to respirable crystalline silica (RCS) during the fabrication of engineered stone-based kitchen countertops has been on the rise in recent years and has become a significant occupational health problem in the United States and globally. Little is known about the presence of nanocrystalline silica (NCS), i.e.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!