Objective: To compare the content of imperatorin and HPLC fingerprint of Baizhi collected from different areas.
Methods: The medicinal materials and seeds of Baizhi from 15 main habitats of 7 provinces and cities were collected, and the seeds were planted in the germplasm resource garden of Suining, Sichuan. The content of imperatorin and HPLC fingerprint were compared using the samples collected from different areas and germplasm resource garden collected and dried at the most suitable harvest date.
Results: The differences on the content of imperatorin and HPLC fingerprint were obvious. The content of imperatorin significantly increased and the HPLC fingerprint were trending to coincide when the herbs were planted in the same place.
Conclusion: The environmental factors and the cultivation technique had great influences on the quality of Baizhi.
Download full-text PDF |
Source |
---|
Arch Dermatol Res
December 2024
Department of Dermatology, the Second Affiliated Hospital, The Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan, University of Chinese Medicine, Changsha, 410005, Hunan, China.
Purpose: Melanin's pivotal role in skin protection and its overproduction leading to hyperpigmentation disorders highlight the necessity of regulating melanogenesis, with autophagy identified as a key degradation pathway. Imperatorin, a compound from Angelica dahurica, has been revealed to reduce melanin in epidermal keratinocytes, with the specific effects and mechanisms unknown. The purpose of this study was to investigate the mechanism by which imperatorin, reduces melanin production in HaCaT cells, with a focus on its potential role in promoting autophagy and regulating the PI3K/Akt signaling pathway.
View Article and Find Full Text PDFCurr Drug Metab
November 2024
State Key Laboratory of Component- based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Background: Cnidii Fructus (CF) is a herbal medicine with pharmacological activities such as antitumor, antiviral, antiallergic, antipruritic effects, and so on.
Objective: In this study, an ultra-high performance liquid chromatography/tandem mass spectrometry (UPLC- MS/MS) method was prepared and verified to measure the concentrations of seven analytes (bergapten, xanthotoxol, xanthotoxin, imperatorin, osthole, isopimpinellin, isoimperatorin) in HepG2 cells.
Methods: The separation of seven analytes was performed on an ACQUITY UPLC® BEH C18 column (2.
Adv Pharmacol Pharm Sci
September 2024
Division of Pharmaceutical Chemistry Faculty of Pharmaceutical Sciences Khon Kaen University, Khon Kaen 40002, Thailand.
The Trikaysornmas formula (TKM) represents a prevalent Thai traditional remedy utilized extensively in Thailand. Its traditional uses include appetite enhancement, functions as a nourishing tonic, and exhibits adaptogenic properties. Comprising fruit, stamen, and bark, this formula embodies the synergy among these three herbs.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
December 2024
NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Institute of Biochemical and Biotechnological Drug. School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China; Key Laboratory of Chemical Biology (Ministry of Education), Shandong University, Jinan 250012, Shandong. China; National Glycoengineering Research Center, Shandong University, Jinan 250012, Shandong, China. Electronic address:
Front Pharmacol
June 2024
Department of Medicine, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, China.
Cervical cancer (CC) ranks as the fourth most prevalent malignant tumor among women worldwide, and is the fourth leading cause of cancer-related mortality. GuiErBai (GEB), a compound preparation developed by our research team, is derived from the ancient Chinese medicine of the Miao nationality and is comprised of podophyllotoxin (PTOX), imperatorin, isoimperatorin, and alkaloids. These individual components have demonstrated notable efficacy in tumor treatment.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!