AI Article Synopsis
- - This study focuses on creating a gastroretentive system for Itopride hydrochloride using floating hydrogel microspheres made from alginate and calcium carbonate.
- - Various tests, including drug content measurement, particle size analysis, and drug release evaluations, confirmed the microspheres had a spherical shape, smooth surface, high loading efficiency, and good buoyancy.
- - The gastroretentive microspheres showed significant benefits in providing antacid, anti-ulcer, and anti-GERD effects over 12 hours compared to traditional dosage forms.
Article Abstract
The present work describes the formulation and evaluation of the gastroretentive system of Itopride hydrochloride. In this research, we have formulated floating hydrogel-based microspheres employing calcium carbonate (CaCO(3)) as a gas forming agent dispersed in alginate matrix. In vitro characterizations such as drug content, particle size, and drug release were carried out. GI motility was determined by administration of charcoal meal to rats. Results demonstrated that prepared microspheres were spherical in shape with smooth surface, good loading efficiency, and excellent buoyancy. The gastro retentive dosage form of itiopride demonstrated significant antacid, anti-ulcer, and anti-GERD activity after 12 hours in comparison with the conventional dosage form.
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| http://dx.doi.org/10.3109/10731191003776751 | DOI Listing |
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