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Neuropathology practice in India: a survey of the current status of diagnostics and training in tertiary care centres.
Pathology
December 2024
Department of Neuropathology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India. Electronic address:
Neuropathology has been in existence as a speciality in India since the 1950s. Its practice has kept pace with the developments in the field, paralleling advancements in neurosurgery and neurosciences, especially in tertiary care centres. This nationwide survey, conducted across 52 centres, provides a comprehensive analysis of diagnostic infrastructure, training opportunities, and challenges in the practice of neuropathology.
View Article and Find Full Text PDFResource availability for CNS tumor diagnostics in the Asian Oceanian region: A survey by the Asian Oceanian Society of Neuropathology committee for Adapting Diagnostic Approaches for Practical Taxonomy in Resource-Restrained Regions (AOSNP-ADAPTR).
Brain Pathol
January 2025
Department of Laboratory Medicine and Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo Metropolitan Hospital Organization, Tokyo, Japan.
The shift toward a histo-molecular approach in World Health Organization classification of central nervous system tumors (WHO CNS5) emphasizes the critical role of molecular testing, such as next-generation sequencing (NGS) and DNA methylation profiling, for accurate diagnosis. However, implementing these advanced techniques is particularly challenging in resource-constrained countries. To address this, the Asian Oceanian Society of Neuropathology committee for Adapting Diagnostic Approaches for Practical Taxonomy in Resource-Restrained Regions (AOSNP-ADAPTR) was initiated to help pathologists in resource-limited regions to implement WHO CNS5 diagnoses using simpler diagnostic tools, mainly immunohistochemistry.
View Article and Find Full Text PDFDual-Double Stem Cell Ovarian Therapy: A Comprehensive Approach in Regenerative Medicine.
Int J Mol Sci
December 2024
Clinic of Endocrinology, Diabetes and Diseases of National Center for Infertility and Endocrinology of Gender, 11000 Belgrade, Serbia.
Dual-double stem cell therapy, which integrates mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs), represents a cutting-edge approach in regenerative medicine, particularly for conditions such as ovarian decline, premature ovarian insufficiency (POI), and induced ovarian failure. This therapy leverages the unique properties of MSCs and HSCs, enhancing tissue repair, immune modulation, and overall regenerative outcomes. MSCs, known for their ability to differentiate into various cell types, provide a supportive microenvironment and secrete bioactive molecules that promote angiogenesis and reduce inflammation.
View Article and Find Full Text PDFInactivity-mediated molecular adaptations: Insights from a preclinical model of physical activity reduction.
Physiol Rep
December 2024
Department of Anatomy, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA.
Insufficient physical activity is associated with increased relative risk of cardiometabolic disease and is an independent risk factor for mortality. Experimentally reducing physical activity rapidly induces insulin resistance, impairs glucose handling, and drives metabolic inflexibility. These adaptations manifest during the early stages of physical inactivity, even when energy balance is maintained, suggesting that inactivity-mediated metabolic reprogramming is an early event that precedes changes in body composition.
View Article and Find Full Text PDFSpatiotemporal Nitric Oxide Modulation via Electrochemical Platform to Profile Tumor Cell Response.
Angew Chem Int Ed Engl
December 2024
Department of Chemistry, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul, Republic of, Korea E-mail: and.
Nitric oxide (NO) is a gaseous molecule intricately implicated in oncologic processes, encompassing the modulation of angiogenesis and instigating apoptosis. Investigation of the antitumor effects of NO is currently underway, necessitating a detailed understanding of its cellular-level reactions. Regulating the behavior of radical NO species has been a significant challenge, primarily due to its instability in aqueous environments by rapid O-induced degradation.
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