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Optimized Scaffold-Free Human 3D Adipose Tissue Organoid Culture for Obesity and Disease Modeling.
SLAS Discov
January 2025
Bonds Biosystems, 27 Strathmore Rd, Natick, MA, USA. Electronic address:
Obesity and type 2 diabetes (T2D) are strongly linked to abnormal adipocyte metabolism and adipose tissue (AT) dysfunction. However, existing adipose tissue models have limitations, particularly in the stable culture of fat cells that maintain physiologically relevant phenotypes, hindering a deeper understanding of adipocyte biology and the molecular mechanisms behind differentiation. Current model systems fail to fully replicate in vivo metabolism, posing challenges in adipose research.
View Article and Find Full Text PDFVaginal versus Laparoscopic Suture for Vaginal Cuff Closure in Total Robot-Assisted Laparoscopic Hysterectomy: A Multicentric Comparative Study.
J Gynecol Obstet Hum Reprod
January 2025
Bichat Hospital, Paris, France; University Paris Cité, Paris, France.
Background: Vaginal cuff closure is an important step in hysterectomy. To date, the literature and data on this procedure are inconsistent, and the optimal approach (i.e.
View Article and Find Full Text PDFArtificial intelligence-enabled obesity prediction: A systematic review of cohort data analysis.
Int J Med Inform
January 2025
Background: Obesity, now the fifth leading global cause of death, has seen a dramatic rise in prevalence over the last forty years. It significantly increases the risk of diseases such as type 2 diabetes and cardiovascular disease. Early identification of obesity risk allows for preventative actions against obesity-related factors.
View Article and Find Full Text PDFAssessment of health behaviors of primary school teachers based on their nutritional knowledge and physical activity: A cross-sectional study in the Asir Region.
PLoS One
January 2025
Department of Public Health, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Background: Primary school teachers play a critical role as educators in imparting healthy eating behaviour and the importance of physical activity to prevent health issues. However, the teachers' health behaviors have not been studied much, particularly in Saudi Arabia. Understanding these factors is essential to developing interventions that enhance teachers' well-being and their ability to influence students positively.
View Article and Find Full Text PDF[Epidemiology and risk factors of persistent arterial hypertension after preeclampsia: a longitudinal study at the Chad-China Friendship Hospital].
Pan Afr Med J
January 2025
Service de Gynéco-Obstérique de l'Hôpital de l'Amitié Tchad-Chine, Ndjamena, Tchad.
Introduction: arterial hypertension (AH) may persist beyond three months postpartum after preeclampsia, increasing the long-term risk of cardiovascular complications. The purpose of this study is to describe the epidemiological aspects and factors associated with persistent hypertension following preeclampsia.
Methods: we conducted a longitudinal descriptive study, from January 2022 to June 2023.
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