A pilomatricoma, also known as pilomatrixoma or calcifying epithelioma of Malherbe, is a benign skin tumor arising from the hair follicle matrix. This tumor is common in children and young adults, especially in the head and neck region. However, pilomatricomas are frequently misdiagnosed or not recognized. The history is typical of a slowly enlarging mass, irregularly contoured, it is fixed to the skin but slides freely over the, underlying tissues, often with a discolouration which varies from red to purple-bluish. Ultrasound examination, MRI-scan and fine-needle aspiration can be helpful if the diagnosis is uncertain. Spontaneous regression has never been observed and malignant degeneration is very rare. Surgical excision with clear margins is the treatment of choice, otherwise recurrence may occur due to incomplete resection.
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Clinical and Histopathological Perspectives of Pilomatrixoma: A Case Report.
Indian J Otolaryngol Head Neck Surg
December 2024
Department of ENT and Head-Neck Surgery, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India.
Article Synopsis
- Pilomatrixoma is a rare, benign tumor from hair follicle cells, mostly seen in kids and young adults, exemplified by an 8-year-old boy with a growing neck lump over three months.* -
- A fine-needle aspiration showed characteristics of an adnexal tumor, leading to surgical removal, which confirmed the diagnosis of pilomatrixoma through histopathology.* -
- The case underscores the need for combined clinical and lab evaluation for accurate diagnosis and highlights successful surgery as key to preventing recurrence, providing valuable insights for pediatric care.*
Clinical and epidemiological characteristics of pilomatricomas in a Mexican pediatric population.
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October 2024
Pediatric Dermatology Service, General Hospital of Mexico Dr. Eduardo Liceaga, Ministry of Health. Mexico City, Mexico.
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- Pilomatricoma is a benign skin tumor commonly found in children, but limited research exists on its epidemiology, often relying on basic statistics.
- A study conducted in Mexico City over six years involved 52 children with confirmed cases of pilomatricoma, revealing patterns such as pain linked to larger lesions and various risk factors, including age and lesion characteristics.
- The findings indicate that pilomatricomas vary in clinical presentation based on size, number, and location, with the head and neck being the most affected areas.
Pilomatricoma presenting as a giant cutaneous horn in an 8-year-old child: A case report and literature review.
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Division of Clinical Dermatology and Cutaneous Science, Department of Medicine, Dalhousie University, Halifax, NS, Canada.
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Retrosynthetic analysis via deep learning to improve pilomatricoma diagnoses.
Comput Biol Med
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Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China; Candidate Branch of National Clinical Research Center for Skin Diseases, Shenzhen, 518020, Guangdong, China; Department of Geriatrics, Shenzhen People's Hospital, (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China. Electronic address:
Background: Pilomatricoma, a benign childhood skin tumor, presents diagnostic challenges due to its manifestation variations and requires surgical excision upon histological confirmation of its characteristic cellular features. Recent artificial intelligence (AI) advancements in pathology promise enhanced diagnostic accuracy and treatment approaches for this neoplasm.
Methods: We employed a multiscale transfer learning model, initiating the training process at high resolutions and adapting to broader scales.
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