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A theoretical model for focal adhesion and cytoskeleton formation in non-motile cells.
J Theor Biol
January 2025
School of Mathematics and Statistics, University of Glasgow, Glasgow, G12 8QQ, United Kingdom. Electronic address:
To function and survive cells need to be able to sense and respond to their local environment through mechanotransduction. Crucially, mechanical and biochemical perturbations initiate cell signalling cascades, which can induce responses such as growth, apoptosis, proliferation and differentiation. At the heart of this process are actomyosin stress fibres (SFs), which form part of the cell cytoskeleton, and focal adhesions (FAs), which bind this cytoskeleton to the extra-cellular matrix (ECM).
View Article and Find Full Text PDFRapid Amplification of Cerebrospinal Fluid Pressure as a Possible Mechanism for Optic Nerve Sheath Bleeding in Infants With Nonaccidental Head Injury.
Invest Ophthalmol Vis Sci
October 2024
John A. Moran Eye Center, Department of Ophthalmology & Visual Sciences, University of Utah, Salt Lake City, Utah, United States.
Article Synopsis
- Subdural hemorrhage along the optic nerve is an indicator of abusive head trauma (AHT) in infants, and the study investigates if this could result from a sudden spike in intracranial pressure affecting cerebrospinal fluid (CSF).
- The researchers created a theoretical model to examine how a brief but intense pressure change at the optic foramen transmits through the CSF-filled subarachnoid space around the optic nerve.
- The findings reveal that a rapid increase in CSF pressure can create a pressure wave that stretches this space, potentially causing tears in blood vessels and leading to hemorrhage—offering insights into the mechanisms behind AHT.
Comprehensive genetic analysis by targeted sequencing identifies risk factors and predicts patient outcome in Mantle Cell Lymphoma: results from the EU-MCL network trials.
Leukemia
December 2024
Second Medical Department, University Hospital Schleswig-Holstein, Kiel, Germany.
Recent studies highlighted genetic aberrations associated with prognosis in Mantle Cell lymphoma (MCL), yet comprehensive testing is not implemented in clinical routine. We conducted a comprehensive genomic characterization of 180 patients from the European MCL network trials by targeted sequencing of peripheral blood DNA using the EuroClonality(EC)-NDC assay. The IGH::CCND1 fusion was identified in 94% of patients, clonal IGH-V-(D)-J rearrangements in all, and 79% had ≥1 somatic gene mutation.
View Article and Find Full Text PDFNovel combined echocardiographic score comprising prognostically validated measures of left ventricular size and function to predict long-term survival following myocardial infarction: A proposal to improve risk stratification.
Echocardiography
September 2024
Department of Cardiology, Royal Brisbane and Women's Hospital, Herston, Australia.
Article Synopsis
- The study aims to enhance risk assessment for patients with mildly reduced or preserved left ventricular ejection fraction (LVEF) after a myocardial infarction (MI) by using a Combined Echo-Score instead of relying solely on LVEF.
- The research analyzed data from over 3,000 MI patients and found that the Echo-Score, which incorporates multiple echocardiographic measures, was a better predictor of all-cause and cardiac mortality than LVEF alone.
- The findings suggested that the Echo-Score's effectiveness was consistent even in groups with LVEF above 40% and 50%, indicating its potential for improving patient prognosis.
Elastic jump propagation across a blood vessel junction.
R Soc Open Sci
July 2024
School of Mathematics and Statistics, University of Glasgow, University Place, Glasgow G12 8SQ, UK.
The theory of small-amplitude waves propagating across a blood vessel junction has been well established with linear analysis. In this study, we consider the propagation of large-amplitude, nonlinear waves (i.e.
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