Aim: to determine the level of different concentration of leptin, adiponectin and resistin among obesity class I and class II population.
Methods: cross sectional study was conducted from June 2006 until January 2007 on 57 patients with obese diabetic and non diabetic Native Javanese. They were divided into obese class I (body mass index [BMI] >25 kg/m2 to <30 kg/m2) and obese class II (BMI >30 kg/m2). Leptin, adiponectin and resistin level concentration were measured.
Results: leptin concentration in obese class I was 13.998 +/- 13.486 ng/ml; adiponectin was 3.98 +/- 1.78 microg/ml; resistin were 25.676 +/- 13.434 ng/ml. Leptin concentration in obese class II 31,074 +/- 26,158 ng/ml; adiponectin 4.75 +/- 1.88 microg/ml; resistin 25.46 +/- 12.26 ng/ml. Leptin concentration was significantly higher in obese class II than obese class I (p=0,002) and there was a positive weak correlation between BMI and leptin level, with Spearman correlation {coefficient correlation 0.363 (p=0.006)}. Adiponectin and resistin concentration was not significantly higher in obese class II than obese class I (p=0.156 and p=0.956).
Conclusion: leptin concentration in obese class II was significantly higher than in obese class I but adiponectin and resistin were not different.
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