Background: Myxofibrosarcoma is common in the extremities of elderly people and is characterized by a high frequency of local recurrence.
Case Presentation: We report a 37 year old female who presented with a 4-month history of facial pain and a 3-month history of painful progressive swelling in the preauricular area. She underwent a total parotidectomy. The tumor was histopathologically and immunohistochemically diagnosed as a low-grade myxofibrosarcoma. The patient was free of disease 9 months after surgery with uneventful post-operative clinical course.
Conclusions: Parotid area swelling should always alert doctors. To our knowledge, this is the first case of parotid myxofibrosarcoma. It should be added to the differential diagnosis of diseases of the parotid. We have to recognize this disease and seek adequate treatment for it.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887780 | PMC |
| http://dx.doi.org/10.1186/1471-2407-10-246 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sarcoma: Last Year's Practice Changing Papers.
Ann Surg Oncol
December 2024
Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Background: In 2023 and 2024, a wide variety of new studies have been published in the field of soft tissue sarcomas, representing the enormous heterogeneity of sarcoma histotypes, anatomical location, treatment variability, and biological behavior.
Patients And Methods: This article summarizes the, in our view, seven most important publications in the field that will have an impact on the surgical practice and future treatment strategies of our patients.
Results: In the last year, we gained more insight in the genetic background of patients with sarcoma from a large Australian study, which will have an impact on future counseling and screening of our patients.
Establishment and characterization of the novel myxofibrosarcoma cell line, SMU-MFS.
Hum Cell
December 2024
Departments of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Myxofibrosarcoma (MFS) is one of the most common soft-tissue sarcomas in elderly patients. Owing to the limited efficacy of chemotherapy and radiotherapy, complete resection is the only available curative treatment. Therefore, developing novel therapies for MFS is important to improve clinical outcomes.
View Article and Find Full Text PDFMyxofibrosarcoma with epithelioid morphology: A clinicopathological study of 44 cases with emphasis on differential diagnosis.
Histopathology
November 2024
Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA.
Article Synopsis
- - The study focused on 44 cases of epithelioid myxofibrosarcoma (eMFS), a rare and aggressive cancer variant, examining factors like morphologic structure and cancer grading, revealing that the majority displayed diffuse epithelioid characteristics and high FNCLCC grades.
- - Among the patients, mostly older adults with a higher incidence in males, local recurrence and metastasis were common; specifically, 10 out of 22 monitored patients developed metastases, typically to regional lymph nodes, regardless of tumor grade.
- - An interesting note is that some cases initially diagnosed as eMFS shared genetic mutations typically seen in other UV-driven cancers, suggesting possible misdiagnosis and the need for careful evaluation
Primary cardiac myxofibrosarcoma in a patient with Ebstein's anomaly: First reported case.
Int J Surg Case Rep
December 2024
Department of Pathology and Lab Medicine, Sri Aurobindo Medical College & Post Graduate Institute, Indore, India.
Article Synopsis
- Primary Cardiac Myxofibrosarcoma (PCM) is a rare and aggressive type of heart tumor, often asymptomatic and can be linked to congenital heart defects like Ebstein's anomaly.
- A case study presented a 38-year-old woman with Ebstein's anomaly who experienced breathing difficulties, leading to the discovery of a mobile cardiac mass that was ultimately diagnosed as PCM after surgical evaluation and histological analysis.
- The findings emphasize the importance of differentiating PCM from other cardiac masses through detailed pathological studies, as early detection and surgical intervention are crucial for improving outcomes in affected patients.
Clinical Outcomes After Definitive Treatment of Soft Tissue Sarcoma of the Hand: A Retrospective Cohort Study of 109 Patients.
J Hand Surg Am
September 2024
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Purpose: The purpose of this study was to provide updated data on oncologic outcomes following definitive surgical treatment of soft tissue sarcoma of the hand in a cohort of 109 patients, as well as to characterize risk factors for poor oncologic and functional outcomes.
Methods: We analyzed data from 109 consecutive patients who had definitive surgical treatment for soft tissue sarcoma of the hand performed between 1996 and 2019 by a single surgeon at a sarcoma center. Primary outcomes included functional outcome (assessed by Musculoskeletal Tumor Society scores), disease-free survival (DFS), and overall survival (OS).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!