Large acetabular defects can be reconstructed using a tantalum Trabecular Metal acetabular component with Trabecular Metal buttress augments. We asked if these reconstructions survived at short-term follow-up. Of 35 patients undergoing acetabular reconstruction with a Trabecular Metal acetabular revision system from 2006, 19 acetabular revisions associated with major bone loss in which we reconstructed the acetabulum with buttress tantalum augments or cup-cage construct combined with a Trabecular Metal shell, were available for evaluation. Mean follow-up was 26 months (range 18-43 months). Mean patient age was 63 years, and 12 patients were women. All defects were classified according to Paprosky and Saleh classifications; there were 13 type IIIA and 6 type IIIB acetabular defects. Five chronic pelvic discontinuities were preoperatively or intraoperatively assessed (Saleh type 5) and a cup-cage construction was employed. No mechanical failure has occurred in any hip, and all patients have radiographically stable cups. Radiographic assessment showed an improvement in the position of the rotation centre of the hip, from a vertical position a mean of 3.5 cm (range 1.6-5.5 cm), to 1.4 cm (range 0.5-2.7 cm) postoperatively. The centre of the femoral head was relocated from a mean of 1.4 cm (range, -3 to 2.6 cm) lateral from the vertical at the teardrop to 3 cm (range 0.2-4 cm). Our early results suggest that buttress tantalum augments, with cup-cage construct for severe bone defects, may be an alternative to other treatment options, but a longer follow-up is necessary.
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http://dx.doi.org/10.1177/11207000100200s720 | DOI Listing |
BMC Oral Health
January 2025
Department of Prosthodontics, Faculty of Dentistry, Hacettepe University, 06230, Sıhhiye/Altındağ, Ankara, Turkey.
Background: The mechanical properties of framework materials significantly influence stress distribution and the long-term success of implant-supported prostheses. Although titanium, cobalt-chromium, zirconia, and polyether ether ketone (PEEK) are widely used, their biomechanical performance under dynamic loading conditions remains insufficiently investigated. This study aimed to evaluate the biomechanical behavior of four framework materials with different Young's modulus using dynamic finite element stress analysis.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center of Biomedical Materials Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
Osteoporosis is a systemic metabolic disease that impairs bone remodeling by favoring osteoclastic resorption over osteoblastic formation. Nanotechnology-based therapeutic strategies focus on the delivery of drug molecules to either decrease bone resorption or increase bone formation rather than regulating the entire bone remodeling process, and osteoporosis interventions suffer from this limitation. Here, we present a multifunctional nanoparticle based on metal-phenolic networks (MPNs) for the treatment of systemic osteoporosis by regulating both osteoclasts and osteoblasts.
View Article and Find Full Text PDFJ Am Acad Orthop Surg
November 2024
From the Medical University of South Carolina, Charleston, SC (Gross and Scott), the University of California Irvine, Orange, CA (Hsu), and the Palomar Health Medical Group, San Diego, CA (Palanca).
The design of total ankle arthroplasty (TAA) systems is rapidly evolving as device companies try to keep pace with the expansion of surgical indications and a refinement of techniques for TAA. Even since the publication of the latest "update," published in 2018, three new designs and three updates on preexisting third-generation implants came onto the market. Improvements in third-generation TAA systems include minimal bone resection, retaining ligamentous support, and anatomic balancing.
View Article and Find Full Text PDFCalcif Tissue Int
January 2025
Musculoskeletal Disease Center (151), Jerry L. Pettis Memorial VA Medical Center, VA Loma Linda Healthcare System, 11201 Benton Street, Loma Linda, CA, 92357, USA.
This study assessed the novel concept that osteoclast-derived Grem1 has regulatory functions in the skeletal response to calcium stress using an osteoclastic Grem1 conditional knockout (cKO) mouse model. The calcium stress was initiated by feeding cKO mutants and wildtype (WT) littermates a calcium-deficient diet for 2 weeks. Deletion of Grem1 in mature osteoclasts did not affect developmental bone growth nor basal bone turnover.
View Article and Find Full Text PDFJ Clin Med
December 2024
Department of Ophthalmology, Kansai Medical University, Hirakata 573-1010, Osaka, Japan.
Primary open-angle glaucoma (POAG), if caused by elevated intraocular pressure (IOP), may require a trabeculotomy (LOT), in which the trabecular meshwork (TM) and Schlemm's canal (ISC) are incised. However, the association between the incision angle and outcomes remains unclear. Therefore, in this study, we investigated the surgical outcomes of a trabeculotomy combined with cataract surgery in patients with POAG over a 12-month follow-up period.
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