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| http://dx.doi.org/10.1016/j.cell.2010.05.014 | DOI Listing |
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Urinary biomarkers for diagnosing acute kidney injury in sepsis in the emergency department.
Heliyon
January 2025
Department of Emergency Medicine, Seoul National University Bundang Hospital (SNUBH), Seongnam-si, South Korea.
Background: Development of acute kidney injury (AKI) in patients with sepsis is associated with increased mortality, highlighting the importance of early detection and management. However, baseline creatinine or urine output measurements are required for AKI diagnosis, which can be challenging in emergency departments (EDs). We aimed to evaluate the association between urinary biomarkers and the AKI diagnosis or 30-day survival status in patients with sepsis in the ED.
View Article and Find Full Text PDFArtificial Intelligence-Guided Identification of IGFBP7 as a Critical Indicator in Lactic Metabolism Determines Immunotherapy Response in Stomach Adenocarcinoma.
J Cell Mol Med
January 2025
Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Due to considerable tumour heterogeneity, stomach adenocarcinoma (STAD) has a poor prognosis and varies in response to treatment, making it one of the main causes of cancer-related mortality globally. Recent data point to a significant role for metabolic reprogramming, namely dysregulated lactic acid metabolism, in the evolution of STAD and treatment resistance. This study used a series of artificial intelligence-related approaches to identify IGFBP7, a Schlafen family member, as a critical factor in determining the response to immunotherapy and lactic acid metabolism in STAD patients.
View Article and Find Full Text PDFDesaturase-dependent secretory functions of hepatocyte-like cells control systemic lipid metabolism during starvation in .
Res Sq
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Nephrogenetics unit, Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
Similar to the mammalian hepatocytes, oenocytes accumulate fat during fasting, but it is unclear how they communicate with the fat body, the major lipid source. Using a modified protocol for prolonged starvation, we show that knockdown (KD) of the sole delta 9 desaturase, Desat1 (SCD in mammals), specifically in oenocytes leads to more saturated lipids in the hemolymph and reduced triacylglycerol (TAG) storage in the fat body. Additionally, oenocytes with KD exhibited an accumulation of lipoproteins and actin filaments at the cortex, which decreased lipoproteins in the hemolymph.
View Article and Find Full Text PDFInsight Into Body Size Evolution in Aves: Based on Some Body Size-Related Genes.
Integr Zool
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Institute of Eastern-Himalaya Biodiversity Research, Dali University, Dali, Yunnan, China.
Article Synopsis
- Birds vary greatly in size, making them key for studying how evolution adapts traits like body size, but the genetic factors involved are still not well understood.
- This study examined 15 genes linked to body size in birds, showing notable adaptive evolution in these genes across different bird lineages, especially highlighting the IGF2BP1 gene's connection to larger body sizes.
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IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways.
Cell Commun Signal
November 2024
Department of Experimental Medicine, Luigi Vanvitelli Campania University, Naples, Italy.
Senescent cells exert their effects through the release of various factors, collectively referred to as the senescence-associated secretory phenotype (SASP). The SASP can induce senescence in healthy cells (secondary senescence), modulate immune system function, reshape the extracellular matrix, and facilitate cancer progression.Among SASP components, certain factors act as key regulators in the induction of secondary senescence.
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