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Exogenous Growth Hormone Exacerbates Post-Irradiation Atherosclerosis in Susceptible Epicardial Coronary Arteries.
Toxicol Pathol
August 2024
Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Cardiac exposure to ionizing radiation can damage both the microvasculature and coronary arteries, as well as increase the long-term risk of heart disease, myocardial fibrosis, and conduction abnormalities. Therapeutic agents capable of promoting recovery from radiation injury to the heart are limited. Growth hormone is linked to improved cardiac function following injury.
View Article and Find Full Text PDFPsychosocial stress increases risk for type 2 diabetes in female cynomolgus macaques consuming a western diet.
Psychoneuroendocrinology
May 2022
Department of Pathology/Comparative Medicine, Wake Forest School of Medicine, USA. Electronic address:
Chronic psychosocial stress is associated with increased risk of many chronic diseases including type 2 diabetes mellitus. However, it is difficult to establish a causal relationship between stress and diabetes in human studies because stressors often are self-reported and may be distant in time from metabolic consequences. Macaques are useful models of the effects of chronic psychosocial stress on health and may develop obesity and diabetes similar to human beings.
View Article and Find Full Text PDFSeychelles Child Development Study: many more avenues for scientific collaboration.
Neurotoxicology
December 2020
University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Nutrition and neurodevelopment: the search for candidate nutrients in the Seychelles Child Development Nutrition Study.
Neurotoxicology
December 2020
Ministry of Health, Republic of Seychelles.
This review examines the role of nutrients in child development and outlines the key nutrients identified as potentially important to neurodevelopment among high fish consumers in the Seychelles Child Development Nutrition Study (SCDNS). It describes the clinical assessment of these nutrients in the blood and breast milk samples collected from the cohort of 300 pregnant women who were recruited, at their first antenatal visit, on the SCDNS. These key nutrients include the long chain polyunsaturated fatty acids (LCPUFA), docosohexaenoic acid (DHA) and arachidonic acid (AA), both of which may affect neurodevelopment in the later stages of fetal growth.
View Article and Find Full Text PDFBackground Left ventricular ( LV ) diastolic dysfunction often precedes heart failure with preserved ejection fraction, the dominant form of heart failure in postmenopausal women. The objective of this study was to determine the effect of oral estradiol treatment initiated early after ovariectomy on LV function and myocardial gene expression in female cynomolgus macaques. Methods and Results Monkeys were ovariectomized and randomized to receive placebo (control) or oral estradiol at a human-equivalent dose of 1 mg/day for 8 months.
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