AI Article Synopsis
- The study aimed to analyze the molecular characteristics of Mycobacterium tuberculosis and factors behind the transmission of drug-resistant strains in Shandong.
- Researchers genotyped tuberculosis isolates from active patients across 13 counties using MIRU methods, finding 143 distinct patterns among 558 samples.
- The findings revealed a significant clustering of strains, particularly from the Beijing family, while suggesting that the transmission of multi-drug resistant strains was not as high as that of susceptible strains, indicating concerns over their ability to spread.
Article Abstract
Objective: To establish the molecular characteristics of Mycobacterium tuberculosis and on factors influencing the recent transmission of drug resistant isolates in Shandong.
Methods: Mycobacterium tuberculosis isolated from active pulmonary tuberculosis patients of 13 counties were genotyped by mycobacterial interspersed repetitive units (MIRU) methods.
Results: 12 loci of MIRU were detected in 558 isolates and a total of 143 MIRU patterns were confirmed. 66 isolates had distinct patterns, and 481 (86.2%) strains were in clusters. Shandong cluster included 177 strains with 74.6% of the isolates belonged to Beijing family. The recent transmission index of multi-drug resistance strains was in lower level, comparing to the susceptible strains.
Conclusion: Our results showed that the Shandong cluster isolates had capacities of facilitating person-to-person transmission and high level of drug resistance.
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