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Whole-Genome Analysis of the Influenza A(H1N1)pdm09 Viruses Isolated from Influenza-like Illness Outpatients in Myanmar and Community-Acquired Oseltamivir-Resistant Strains Present from 2015 to 2019.
Viruses
August 2024
Infectious Diseases Research Center of Niigata University in Myanmar (IDRC), Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan.
Article Synopsis
- The study examines the genetic characteristics of influenza A(H1N1)pdm09 strains found in Myanmar between 2015 and 2019, utilizing advanced sequencing techniques to analyze 60 virus isolates.
- It identifies distinct clades for each year’s virus, noting that strains from these years were genetically different from WHO-recommended Southern Hemisphere vaccine strains.
- The researchers also discovered a virus with reassortment and three strains with the H275Y mutation, indicating reduced effectiveness against antiviral treatments, highlighting the need for ongoing monitoring of flu virus genetics for vaccine development.
Community- and hospital-acquired infections with oseltamivir- and peramivir-resistant influenza A(H1N1)pdm09 viruses during the 2015-2016 season in Japan.
Virus Genes
February 2017
Division of International Health, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, 951-8510, Japan.
We report five cases of community- and hospital-acquired infections with oseltamivir- and peramivir-resistant A(H1N1)pdm09 viruses possessing the neuraminidase (NA) H275Y mutation during January-February 2016 in Japan. One case was hospitalized and was receiving oseltamivir for prophylaxis. The remaining four cases were not taking antiviral drugs at the time of sampling.
View Article and Find Full Text PDFA randomized study of standard versus double dose oseltamivir for treating influenza in the community.
Antivir Ther
November 2016
NCIRS, The Children's Hospital, Westmead, NSW, Australia.
Background: The neuraminidase inhibitors are the treatment of choice for influenza virus infection. Oseltamivir-resistant (OsR) strains of influenza A(H1N1)pdm09 are described, but the effect of higher dose oseltamivir on efficacy, safety and emergence of resistance has not been addressed in the developed setting in outpatients. The objectives of the study were to compare standard dose (SD) versus double dose (DD) oseltamivir regimens for frequency of detecting OsR influenza virus, clinical disease resolution, virological clearance and adverse events.
View Article and Find Full Text PDFFrequency of oseltamivir resistance in Sydney, during the Newcastle outbreak of community transmitted oseltamivir-resistant influenza A(H1N1)pdm09 virus, Australia, June to August 2011.
Euro Surveill
July 2012
Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, Australia.
Although oseltamivir-resistant pandemic influenza A(H1N1)pdm09 is uncommon in immunocompetent individuals, a recent report from Newcastle, Australia, showed the first sustained community spread, from June to August 2011, of oseltamivir-resistant influenza A(H1N1)pdm09 virus carrying the H275Y neuraminidase (NA) mutation. To determine the frequency and the extent of this viral variant spread in the nearest major city to Newcastle, we performed a sequencebased genotypic assessment on samples from 143 oseltamivir untreated and 23 oseltamivir post-treatment individuals with influenza collected contemporaneously in Sydney, 120 km southwest of Newcastle. The detection of two of 143 (1.
View Article and Find Full Text PDFCharacteristics of a widespread community cluster of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza in Australia.
J Infect Dis
July 2012
WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia.
Background: Oseltamivir resistance in A(H1N1)pdm09 influenza is rare, particularly in untreated community cases. Sustained community transmission has not previously been reported.
Methods: Influenza specimens from the Asia-Pacific region were collected through sentinel surveillance, hospital, and general practitioner networks.
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