AI Article Synopsis

  • Anesthesia has been a significant medical advancement since the first public demonstration of ether, which was flammable but used as the main agent for over a century.
  • In 1955, a safer non-flammable anesthetic called halothane was introduced, becoming the most commonly used agent in the U.S. after FDA approval in 1958.
  • Halothane's use ended in 1988 due to liver toxicity, and Dr. C. Ronald Stephen of Duke University was confirmed as the first to use and publish findings on halothane anesthesia in the U.S.

Article Abstract

Anesthesia is one of the most valued discoveries in all of history. Almost immediately after the first public demonstration of ether anesthesia, a search for a better drug began. Ether, despite its flammability, persisted as the primary inhalation agent for over a hundred years. The breakthrough came with the introduction of a non-flammable volatile anesthetic called halothane in 1955. The drug was approved by the FDA in 1958 and quickly became the most commonly used agent in the United States. It was a quantum leap forward in the safety of anesthetic drugs. It became obsolete in 1988 because of hepatotoxicity. Three eminent anesthesiologists: Drs. Abajian of Vermont, Siker of Pittsburgh and Stephen of Duke could have been the first to use halothane in the USA. My review of the documents and writings of the three confirm that Dr. C. Ronald Stephen of Duke University was indeed the first to use and publish on halothane anesthesia in the USA.

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1522-8649(08)50011-4DOI Listing

Publication Analysis

Top Keywords

united states
8
ronald stephen
8
stephen duke
8
halothane
4
halothane united
4
states ronald
4
stephen 1916-2006
4
1916-2006 anesthesia
4
anesthesia valued
4
valued discoveries
4

Similar Publications

This study analyzes 2022 data from SAMHSA's Mental Health Client-Level Data (MH-CLD) to investigate ADHD prevalence and comorbidity. The findings reveal that 10.70% of the 5,899,698 patients were diagnosed with ADHD, indicating a high demand for targeted resources.

View Article and Find Full Text PDF

Background: Giant cell arteritis (GCA) is the most common vasculitis in patients older than 50 years and is considered a "do not miss" diagnosis. However, it remains a diagnostic challenge given overlapping clinical syndromes such as non-arteritic anterior ischemic optic neuropathy (NAION) and poorly explored imaging findings.

Materials And Methods: In this retrospective study between the time period of January 2013 and December 2021, a total of 13 consecutive patients with a pathological diagnosis of GCA and 8 patients with clinical diagnosis of NAION were isolated.

View Article and Find Full Text PDF

While the content of subjective (personal) experience is inaccessible to external observers, behavioral proxies can frame the nature of that experience and suggest its cognitive requirements. Directed attention is widely recognized as a feature of animal awareness. This descriptive study used the frequency of gaze shifts in lizards and birds as an indicator of the rate at which the animals change the perceptual segmentation of their ongoing experience.

View Article and Find Full Text PDF

The and of Vincent van Gogh: neuropeptides of bondedness and loss.

Front Psychol

December 2024

Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, United States.

We introduce two Korean-named yet transcultural feelings, and , to fill gaps in neuroscientific understanding of mammalian bondedness, loss, and aggression. is a visceral sense of connectedness to a person, place, or thing that may arise after proximity, yet does not require intimacy. The brain opioid theory of social attachment (BOTSA) supports the idea that involves increased activity of enkephalins and beta-endorphins.

View Article and Find Full Text PDF

This study investigates the acquisition of sentence focus in Russian by adult English-Russian bilinguals, while paying special attention to the relative contribution of constituent order and prosodic expression. It aims to understand how these factors influence perceived word-level prominence and focus assignment during listening. We present results of two listening tasks designed to examine the influence of pitch cues and constituent order on perceived word prominence (Experiment 1) and focus assignment (Experiment 2) during the auditory comprehension of SV[O] and OV[S] sentences in Russian.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!