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Genetic variation in TGF-beta 1 gene promoter and risk of gestational trophoblastic disease. | LitMetric
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Genetic variation in TGF-beta 1 gene promoter and risk of gestational trophoblastic disease.

Alamtaj Samsami Dehaghani Tarlan Zamanpour Sirous Naeimi Safoura Sameni Minoo Robati Abbas Ghaderi

J Reprod Med

Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran.

Published: July 2010

Objective: To examine the relationship of transforming growth factor beta 1 (TGF-beta 1) gene polymorphisms at promoter positions -509 (C/T) and -800 (G/A) with the risk of gestational trophoblastic disease (GTD) as compared to normal controls

Study Design: Polymerase chain reaction-restriction fragment length polymorphism was performed on peripheral blood of 102 patients with GTD and 124 normal, healthy, pregnant women as the control group.

Results: In this study, TGF-beta 1 gene polymorphisms at positions -509 (C/T) and -800 (G/A) failed to correlate with GTD.

Conclusion: Our findings suggest that promoter gene polymorphisms of TGF-beta 1 do not play major roles in GTD and may not be risk factors for this disease.

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