AI Article Synopsis
- Overexpression or amplification of the EGFR gene occurs in 35-45% of glioblastoma tumors and is linked to a worse prognosis.
- This study explores how the drug cetuximab affects EGFR signaling pathways crucial for the growth and survival of these tumor cells.
- Findings suggest that even with cetuximab treatment, EGFR is not sufficiently downregulated, and its overexpression may not accurately predict patient response to the treatment.
Article Abstract
Overexpression and/or amplification of the epidermal growth factor receptor (EGFR) is present in 35-45% of primary glioblastoma multiforme tumors and has been correlated with a poor prognosis. In this study, we investigated the effect of cetuximab and intracellular signaling pathways downstream of EGFR, important for cell survival and proliferation. We show insufficient EGFR downregulation and competition with endogenous EGFR ligands upon cetuximab treatment. Dose-response experiments showed inhibition of EGFR phosphorylation without affecting two of the prominent downstream signaling pathways. Our results indicate that amplification and/or overexpression of EGFR is an unsatisfactory predictor for response to cetuximab.
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| http://dx.doi.org/10.3109/07357907.2010.483506 | DOI Listing |
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