Objective: Pegylated interferon plus ribavirin is the standard treatment for chronic hepatitis C. Sustained virological response (SVR) rates of up to 60% are reported in randomized controlled trials, but it is unclear whether the results from such trials are reproducible in the clinical routine setting. We investigated consecutive treatment-naïve chronic hepatitis C patients at our center to examine the efficacy of treatment with pegylated interferon plus ribavirin in clinical routine.
Materials And Methods: Between 2000 and 2006 we treated a total of 219 patients with pegylated interferon alpha (2a or 2b) and ribavirin (800-1200 mg/d). Among them, 34.8% of patients infected with HCV genotypes 1/4/6 and 18.4% of those with genotypes 2/3 had advanced fibrosis or cirrhosis (F3-F4). For analysis of outcome we subdivided our series into two groups of patients: those who fulfilled standard inclusion criteria in randomized controlled trials and those who did not.
Results: The overall SVR rate was 44.3%. In patients with F0-F2 an SVR was achieved in 52.5%; in those with F3-F4 the SVR rate was 20.8%. In patients infected with genotypes 1/4/6 the SVR rate was 35.4% (SVR: F0-F2 47.7%; F3-F4 19.6%); in those with genotypes 2/3 the rate was 67.8%. The SVR rate in patients with unfavorable baseline factors was significantly lower (32.4% vs. 50%; P = 0.017) and they were more likely to be non-responders (30.9% vs. 13.8%).
Conclusion: In everyday clinical practice, up to one-third of patients show unfavorable baseline factors for antiviral therapy, resulting in worse therapeutic outcome. Differences in therapeutic outcome are influenced by patient selection and by the proportion and severity of the underlying liver disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00508-010-1364-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prediction of pre-eclampsia using maternal hemodynamic parameters at 12 + 0 to 15 + 6 weeks.
Ultrasound Obstet Gynecol
January 2025
Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.
Objectives: To compare the maternal hemodynamic profile at 12 + 0 to 15 + 6 weeks' gestation in women who subsequently developed pre-eclampsia (PE) and those who did not, and to assess the screening performance of maternal hemodynamic parameters for PE in combination with the Fetal Medicine Foundation (FMF) triple test, including maternal factors (MF), mean arterial pressure (MAP), uterine artery pulsatility index and placental growth factor.
Methods: This was a prospective case-control study involving Chinese women with a singleton pregnancy who underwent preterm PE screening at 11 + 0 to 13 + 6 weeks' gestation using the FMF triple test, between February 2020 and February 2023. Women identified as being at high risk (≥ 1:100) for preterm PE by the FMF triple test were matched 1:1 with women identified as low risk (< 1:100) for maternal age ± 3 years, maternal weight ± 5 kg and date of screening ± 14 days.
Automated craniofacial biometry with 3D T2w fetal MRI.
PLOS Digit Health
December 2024
Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, United Kingdom.
Objectives: Evaluating craniofacial phenotype-genotype correlations prenatally is increasingly important; however, it is subjective and challenging with 3D ultrasound. We developed an automated label propagation pipeline using 3D motion- corrected, slice-to-volume reconstructed (SVR) fetal MRI for craniofacial measurements.
Methods: A literature review and expert consensus identified 31 craniofacial biometrics for fetal MRI.
Determination and visualization of moisture content in Camellia oleifera seeds rapidly based on hyperspectral imaging combined with deep learning.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China; College of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address:
Moisture content (MC) is crucial for the storage, transportation, and processing of Camellia oleifera seeds. The purpose of this study was to investigate the feasibility for detecting MC in Camellia oleifera seeds using visible near-infrared hyperspectral imaging (VNIR-HSI) (374.98 ∼ 1038.
View Article and Find Full Text PDFPredicting age at first calving of dairy breed calves using whale optimization-based ensemble learning framework.
Sci Rep
December 2024
School of Computer Science Engineering and Information Systems, Vellore Institute of Technology, Vellore, India.
Dairy product requirement and the demand-supply gap of milk in Ethiopia have been increasing at an alarming rate due to various factors such as shortage of animal's feeds, feed staffs, feed costs, and poor genetic merits of the local breeds of the country. This problem can be lessened by selecting best breed and modern animal breeding facilities, which require technologies like big data analysis and machine learning. In this study, a prediction model that can predict age at first calving of weaned calves based on their pre-weaning and weaning parameters, including dam's parity number, season of calving, birth weight, pre-weaning health status, pre-weaning average daily weight gain (ADG), weaning age and weaning weight is developed.
View Article and Find Full Text PDFNormal echocardiographic findings in healthy pregnant women: A narrative review of the literature.
Curr Probl Cardiol
December 2024
Cardiology Section, Internal Medicine Department, Universidad de Antioquia, Medellín, Colombia; Cardiopulmonary and Peripheral Vascular Service, Hospital San Vicente Fundación, Medellín, Colombia; Cardio-Obstetric Clinical Leader, Hospital San Vicente Fundación, Medellín, Colombia.
During pregnancy, significant physiological changes occur that result in cardiac remodeling and altered functional performance, though these are generally reversible postpartum. Pregnancy increases the cardiovascular system's demand, requiring substantial adaptations such as elevated cardiac output (CO), plasma volume, stroke volume (SV), and heart rate (HR), alongside a reduction in systemic vascular resistance (SVR) and mean arterial pressure. These adaptations, essential to meet the hemodynamic needs of both the mother and fetus, often differ from standard echocardiographic measurements used to evaluate cardiac function, making interpretation challenging.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!