CSF baclofen levels after intrathecal administration in severe spasticity.

Eur J Clin Pharmacol

Laboratoire de Pharmacie Galénique, Faculté des Sciences Pharmaceutiques, Toxicologie Fondamentales du CNRS, Toulouse, France.

Published: July 1991

The pharmacokinetic parameters in the CSF of baclofen given to 4 patients as an intrathecal bolus are reported. Considerable inter-individual variability in the parameters was observed. The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.08 l.h-1. In order to optimize treatment, it is suggested that CSF baclofen levels be matched to changes in Hoffman's monosynaptic reflex (H reflex).

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http://dx.doi.org/10.1007/BF00265844DOI Listing

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