Aim: Older drivers are increasing in number and they often have health conditions that place them at high risk for motor vehicle crashes. The aims of this study were to: (i) evaluate the feasibility and acceptability of screening inpatients and outpatients over the age of 60 years for age-related driving disorders; and (ii) determine the patient characteristics associated with screening outcomes.
Methods: A convenience sample of 397 participants completed age-related driving disorders screening at University of California, San Diego, inpatient and outpatient settings. Eligibility criteria included California-licensed drivers over the age of 60 years who were English or Spanish speaking. Baseline screening included driving habits, restrictions, history of crashes, and medical history, including medications. Screening included visual acuity, visual fields, three strength frailty tests and two cognitive tests.
Results: The average age of participants was 72 years; 59% were male and 12% Hispanic. Almost 20% of older adults failed at least one test, and were labeled 'high risk' for age-related driving disorders. In multivariate analysis, significant predictors of high-risk status were age, male sex, self-restrictions of driving and use of larger amounts of prescription drugs. Screening took approximately 15 min and participant satisfaction was high.
Conclusion: A brief screening evaluation identified one in five adults to be 'high risk' for age-related driving disorders. Screening was effective in both outpatient and inpatient settings, was well received and simple to administer.
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http://dx.doi.org/10.1111/j.1447-0594.2010.00622.x | DOI Listing |
Scand J Med Sci Sports
January 2025
Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Physical inactivity and sedentary behavior are associated with higher risks of age-related morbidity and mortality. However, whether they causally contribute to accelerating biological aging has not been fully elucidated. Utilizing the largest available genome-wide association study (GWAS) summary data, we implemented a comprehensive analytical framework to investigate the associations between genetically predicted moderate-to-vigorous leisure-time physical activity (MVPA), leisure screen time (LST), and four epigenetic age acceleration (EAA) measures: HannumAgeAccel, intrinsic HorvathAgeAccel, PhenoAgeAccel, and GrimAgeAccel.
View Article and Find Full Text PDFNeurobiol Dis
January 2025
Vulnerable Brain Lab, Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada. Electronic address:
Alzheimer's disease (AD) is a progressive neurodegenerative disease that accounts for two-thirds of all dementia cases, and age is the strongest risk factor. In addition to the amyloid hypothesis, lipid dysregulation is now recognized as a core component of AD pathology. Gangliosides are a class of membrane lipids of the glycosphingolipid family and are enriched in the central nervous system (CNS).
View Article and Find Full Text PDFJ Cell Mol Med
January 2025
NHC Key Lab of Hormones and Development and Tianjin Key Lab of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Institute of Endocrinology, Tianjin, China.
Proper differentiation of bone marrow stromal cells (BMSCs) into adipocytes is crucial for maintaining skeletal homeostasis. However, the underlying regulatory mechanisms remain incompletely understood, posing a challenge for the treatment of age-related osteopenia and osteoporosis. Here, through comprehensive gene expression analysis during BMSC differentiation into adipocytes, we identified the forkhead transcription factor Foxk2 as a key regulator of this process.
View Article and Find Full Text PDFMaturitas
December 2024
Unit Healthy Living and Work, Netherlands Organization for Applied Scientific research (TNO), Sylviusweg 71, 2333 BE Leiden, the Netherlands; Department of Internal Medicine, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, the Netherlands. Electronic address:
Objectives: Type 2 diabetes is a highly prevalent age-related chronic condition, with complex and heterogeneous pathogenesis. A 5-point oral glucose tolerance test can identify type 2 diabetes subtypes or "diabetypes" based on the degree of insulin resistance in muscle and/or liver, and beta-cell dysfunction. Due to its costly and invasive nature, the oral glucose tolerance test is not scalable.
View Article and Find Full Text PDFAlzheimers Dement
January 2025
Department of Neuroscience, Yale Medical School, New Haven, Connecticut, USA.
Aging rhesus macaques provide a unique model for learning how age and inflammation drive early-stage pathology in sporadic Alzheimer's disease, and for testing potential therapeutics. Unlike mice, aging macaques have extensive association cortices and inflammatory signaling similar to humans, are apolipoprotein E ε4 homozygotes, and naturally develop tau and amyloid pathology with marked cognitive deficits. Importantly, monkeys provide the unique opportunity to study early-stage, soluble hyperphosphorylated tau (p-tau), including p-tau217.
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