A total of 1038 Muscovites (740 males and 298 females) aged 20 to 60 years were examined using a broad range of clinical and diagnostic methods. In the study cohort, the prevalence of all diseases taken together was 1533 cases per 1000 examinees, the number of cases being 1108.1 and 2590.6% per hundred among men and women, respectively. In males, endocrine diseases (27.3%) rated first, next were cardiovascular (23.5%) and digestive (18.8%) diseases that occupied the second and third places, respectively. In females, diseases of genital organs (breast, ovaries, corpus and cervix uteri) were the most common pathology (about 50%), cardiovascular (15.8%) and digestive (10.6%) diseases ranked second and third, respectively. Metabolic syndrome was virtually equally present in both sexes: 22.7% in males and 26.5% in females. The application of this approach can reveal abnormalities in their early stage, follow their course, and develop packages of adequate preventive measures.

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