Background: Transforming growth factor-beta (TGF-beta) levels are elevated in the nasal mucosa in allergic rhinitis. However, because TGF-beta is secreted extracellulary in latent complexes, it remains unclear whether the local TGF-beta expression actually drives active signaling and affects the pathophysiology of allergic rhinitis. The objective of this study is to investigate whether TGF-beta signaling is activated in allergic rhinitis and plays a role in the pathophysiology of allergic rhinitis.
Methods: An ovabumin (OVA)-sensitized and -nasally challenged mouse model of allergic rhinitis was established and phosphorylation of Smad2 in the nasal mucosa was examined by immunohistochemistry. In addition, the effects of the pharmacological inhibition of endogenous TGF-beta signaling on the allergic rhinitis model were histologically examined. Furthermore, phosphorylation of Smad2 in the nasal mucosa samples obtained from patients with allergic rhinitis was also evaluated.
Results: In the mouse model of allergic rhinitis, OVA challenge induced phosphorylation of Smad2 predominantly in epithelial cells in the nasal mucosa. In addition, the administration of an inhibitor of TGF-beta type I receptor kinase activity during OVA challenge suppressed goblet cell hyperplasia in the nasal mucosa. Furthermore, phosphorylated Smad2 expression increased in nasal epithelial cells in patients with allergic rhinitis.
Conclusions: These results suggest that TGF-beta signaling is activated in epithelial cells in the nasal mucosa in allergic rhinitis and may contribute to the development of goblet cell hyperplasia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2332/allergolint.10-SC-0172 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An evaluation of Asthma control using the Asthma control test in patients at the University Hospital, Agadir, Morocco.
Niger Med J
January 2025
Health Sciences Research and Innovation Laboratory Medical School of Medicine & Pharmacy of Agadir, Ibn Zohr University, Agadir-Morocco.
Background: Asthma is a common chronic disease, and asthma control is the major therapeutic objective, thus ensuring a good health-related quality of life. This study aimed to evaluate the level of asthma control in a sample of asthmatic patients followed in allergology consultation during our training using the asthma control test (ACT) and its correlation with other parameters.
Methodology: This is a cross-sectional study of 66 asthmatic patients who were followed in pulmonology consultation at Agadir University Hospital after completing the asthma control test questionnaire over 6 months (June to December 2021).
Otorhinological disorders among pregnant women attending the obstetric clinic at Benjamin Mkapa Hospital, Tanzania.
Niger Med J
January 2025
Department of Otorhinolaryngology, Muhimbili University of Health and Allied Sciences, Dares Salaam, Tanzania.
Background: Pregnancy leads to physiological changes primarily driven by hormones like oestrogen and progesterone. Such changes are multi-systemic in nature including involvement of the ear, nose and throat. Such changes impair the quality of the life of pregnant women and thus requires prompt intervention during pregnancy.
View Article and Find Full Text PDFSpecificity and sensitivity of questionnaires in the diagnosis of allergic diseases.
Postepy Dermatol Alergol
December 2024
Department of Public Health, Medical University of Warsaw, Warsaw, Poland.
Introduction: Due to their widespread character, allergic diseases are a significant challenge in the field of public health and clinical practice. The available clinimetric tools, including standardized and validated questionnaires, play an important role in determining the incidence of a particular allergic disease in the targeted population.
Aim: We attempted to evaluate the specificity and sensitivity of modified and standardized questions from the ISSAC and ECRHS questionnaires in the diagnosis of allergic diseases.
Technical validation of controlled exposure to cat dander in the specialized particulate control environmental exposure unit (SPaC-EEU).
Allergy Asthma Clin Immunol
January 2025
Allergy Research Unit, Kingston Health Sciences Center - KGH Site, Kingston, ON, Canada.
HMOX1 as a potential drug target for upper and lower airway diseases: insights from multi-omics analysis.
Respir Res
January 2025
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China.
Background: Oxidative stress is key in inflammatory airway diseases. Heme oxygenase 1 (HMOX1) regulates oxidative stress, but its role in airway diseases needs exploration.
Methods: Differentially expressed genes (DEGs) between healthy nasal mucosa and chronic rhinosinusitis with nasal polyps (CRSwNP) were identified from Gene Expression Omnibus (GEO).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!