Diagnosis of fatal pulmonary fat embolism with minimally invasive virtual autopsy and post-mortem biopsy.

Leg Med (Tokyo)

Department of Legal Medicine, Centre of Forensic Imaging and Virtopsy, University of Berne, Buehlstrasse 20, 3012 Bern, Switzerland.

Published: September 2010

We report a case of a 78-year-old female with a proximal femur fracture caused by an accidental fall who died suddenly 1h after orthopaedic prosthesis insertion. Post-mortem computed tomography (CT) scan and histological examination of samples obtained with post-mortem percutaneous needle biopsies of both lungs were performed. Analysis of the medical history and the clinical scenario immediately before death, imaging data, and biopsy histology established the cause of death without proceeding to traditional autopsy. It was determined to be acute right ventricular failure caused by massive pulmonary fat embolism. Although further research in post-mortem imaging and post-mortem tissue sampling by needle biopsies is necessary, we conclude that the use of CT techniques and percutaneous biopsy, as additional tools, can offer a viable alternative to traditional autopsy in selected cases and may increase the number of minimally invasive forensic examinations performed in the future.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.legalmed.2010.04.003DOI Listing

Publication Analysis

Top Keywords

pulmonary fat
8
fat embolism
8
minimally invasive
8
needle biopsies
8
traditional autopsy
8
post-mortem
5
diagnosis fatal
4
fatal pulmonary
4
embolism minimally
4
invasive virtual
4

Similar Publications

Effect of the S100A9/AMPK pathway on PM2.5-mediated mouse lung injury.

Iran J Basic Med Sci

January 2025

Graduate school, Shenyang Medical College, Shenyang. No. 146, Huanghe North Street, Shenyang, People's Republic of China.

Objectives: Particulate matter 2.5 (PM2.5), particles with an aerodynamic diameter less than 2.

View Article and Find Full Text PDF

Oxidative balance score (OBS) is a composite measures that assess the balance between pro-oxidant and antioxidant factors in an individual's diet and lifestyle, with higher scores indicating greater antioxidant exposure. Despite its potential significance, there is a limited body of research exploring the relationship between OBS and all-cause and cardiovascular disease (CVD) mortality specifically in younger patients with diabetes. We aimed to investigate the possible relationship between OBS and all-cause and CVD mortality in younger patients with diabetes.

View Article and Find Full Text PDF

Introducing internal allocation factors for assessing aggregate pesticide exposure across multiple pathways and routes.

J Hazard Mater

January 2025

School of Public Health (Shenzhen), Sun Yat-sen University, Guangdong 510275, China. Electronic address:

In the health risk assessment of pesticides, methods for external exposure assessment have been well developed. However, quantifying the contribution of various exposure pathways or routes to internal dose remains challenging. This study introduced the internal allocation factor (IAF) for 319 pesticides to investigate the impact of different exposure pathways and routes on chemical distribution within the human body.

View Article and Find Full Text PDF

CIDEC/FSP27 exacerbates obesity-related abdominal aortic aneurysm by promoting perivascular adipose tissue inflammation.

Life Metab

February 2025

Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Fudan University, Shanghai 200438, China.

Abdominal aortic aneurysm (AAA) is strongly correlated with obesity, partially due to the abnormal expansion of abdominal perivascular adipose tissue (PVAT). Cell death-inducing DNA fragmentation factor-like effector C (CIDEC), also known as fat-specific protein 27 (FSP27) in rodents, is specifically expressed in adipose tissue where it mediates lipid droplet fusion and adipose tissue expansion. Whether and how CIDEC/FSP27 plays a role in AAA pathology remains elusive.

View Article and Find Full Text PDF

SHOC2 plays an oncogenic or tumor-suppressive role by differentially targeting the MAPK and mTORC1 signals in liver cancer.

Life Med

June 2024

Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education) of the Second Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310029, China.

SHOC2 is a scaffold protein that activates the RAS-MAPK signal. Our recent study showed that SHOC2 is also a negative regulator of the mTORC1 signal in lung cancer cells. Whether and how SHOC2 differentially regulates the RAS-MAPK vs.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!