AI Article Synopsis
- * A study examined 11 patients (7 men, 4 women, and 1 child), highlighting that while most had typical symptoms, blood eosinophilia was absent in five cases and chest involvement was noted in two.
- * Diagnosis should be considered in patients with limb myalgia and induration; treatment is primarily with systemic corticosteroids, with only one case experiencing relapse linked to systemic sclerosis.
Article Abstract
Purpose: Eosinophilic fasciitis or Shulman's disease is a rare condition of unknown etiology.
Methods: We report a retrospective case series of 11 patients with eosinophilic fasciitis (seven men and four women, including a single pediatric case) and perform a systematic literature review to determine the main features of this disease.
Results: Mean age of the patients was 46 years. Subcutaneous induration of limbs observed in all the patients was the major presenting symptom. The induration was atypically located in the chest area in two patients. Blood eosinophilia was absent in five cases. Histological fasciitis was demonstrated in all patients and eosinophilic infiltration was present in seven patients. Relapse of subcutaneous induration was observed in only one patient who gradually developed systemic sclerosis.
Conclusion: Diagnosis of eosinophilic fasciitis should be considered in the presence myalgia and subcutaneous induration of limbs, blood eosinophilia and hypergammaglobulinemia. Treatment is based on systemic corticosteroids.
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| http://dx.doi.org/10.1016/j.revmed.2010.03.344 | DOI Listing |
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Eosinophilic fasciitis (EF) poses a diagnostic challenge owing to its uncommon occurrence and aetiology that remains poorly understood. We report a case of a 79-year-old woman with a prolonged history of breast cancer exhibiting EF with concomitant pelvic metastases. This case underscores EF's potential as an indicator signaling a potential resurgence of cancer, highlighting its significance as a red flag of disease recurrence.
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