AI Article Synopsis
- GABA mediates inhibition in the brain by binding to specific receptor sites, but research findings on this process are inconsistent.
- The controversies may stem from the use of unnatural buffers in GABA receptor preparation and binding assays.
- A new model is proposed, suggesting that GABA receptors work as a tetramer, with binding sites that operate cooperatively in physiological conditions.
Article Abstract
Gamma-aminobutyric acid (GABA) mediates the postsynaptic inhibition via reversible binding to specific recognition (receptor) sites. Despite extensive research, the results from binding and functional response measurements remains controversial. It is suggested that controversies may partly result from the use of non-physiological buffer during the preparation and binding assay of the GABA receptor. To account for the positive cooperativity found in physiological medium, a hypothetical model of the GABA receptor is proposed as a tetramer of binding sites operating in a cooperative fashion.
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| http://dx.doi.org/10.1016/0197-0186(85)90026-9 | DOI Listing |
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