The Model of Uptake with Instantaneous Adsorption and Efflux, MUIAE, describing and predicting the overall Cd uptake by the metal-resistant bacterium Cupriavidus metallidurans CH34, is presented. MUIAE takes into account different processes at the bacteria-medium interface with specific emphasis on the uptake and efflux kinetics and the decrease in bulk metal concentration. A single set of eight parameters provides a reasonable description of experimentally determined adsorbed and internalized Cd, as well as the evolution of dissolved Cd concentrations with time, for an initial Cd concentration between 10(-8) and 10(-4) M, covering the situation of contaminated environments and heavily polluted effluents. The same set of parameters allowed successful prediction of the internalized and adsorbed Cd as a function of the measured free Cd ion concentration in the presence of natural and anthropogenic ligands. The findings of the present study reveal the key role of Cd efflux and bulk depletion on the overall Cd uptake by C. metallidurans, and the need to account for these processes to understand and improve the efficiency of the metal removal from the contaminated environment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/es100687h | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Membrane drug transporters in cancer: From chemoresistance mechanism to therapeutic strategies.
Biochim Biophys Acta Rev Cancer
January 2025
Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau, China; Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau, China. Electronic address:
Chemoresistance is a multifactorial phenomenon and the primary cause to the ineffectiveness of oncotherapy and cancer recurrence. Membrane drug transporters are crucial for drug delivery and disposition in cancer cells. Changes in the expression and functionality of these transporters lead to decreased intracellular accumulation and reduced toxicity of antineoplastic drugs.
View Article and Find Full Text PDFUnseen Enemy: Mechanisms of Multidrug Antimicrobial Resistance in Gram-Negative ESKAPE Pathogens.
Antibiotics (Basel)
January 2025
Institute of Physiology and Pharmacology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Multidrug antimicrobial resistance (AMR) represents a formidable challenge in the therapy of infectious diseases, triggered by the particularly concerning gram-negative , , , , , and spp. (ESKAPE) pathogens. Designated as a "priority" in 2017, these bacteria continue to pose a significant threat in 2024, particularly during the worldwide SARS-CoV-2 pandemic, where coinfections with ESKAPE members contributed to worsened patient outcomes.
View Article and Find Full Text PDFJasmonic acid improves cadmium tolerance in rice (Oryza sativa) by reducing the production of nitric oxide.
Ecotoxicol Environ Saf
January 2025
College of Advanced Agricultural Sciences, Zhejiang A & F University, Hangzhou 311300, China; State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Science, Nanjing 210008, China. Electronic address:
The involvement of jasmonic acid (JA) in the rice's response to cadmium (Cd) stress is well recognized, though the underlying mechanisms remain unclear. In this study, exposure to Cd stress rapidly elevated endogenous JA concentrations in rice roots, meanwhile, a mutant coleoptile photomorphogenesis 2 (cpm2) which produces less JA, was more sensitive to Cd stress than its wild type (WT). JA mitigated Cd toxicity by decreasing Cd absorption in root cell wall and shoot, which was achieved by up-regulating the expression of the Cd-chelation and efflux-related genes such as OsHMA3, OsABCG36 and OsCAL1; down-regulating the transcript level of the Cd uptake and translocation-related genes, including OsHMA2, OsCCX2, OsNRAMP1/5, and OsZIP5/7.
View Article and Find Full Text PDFMultifunctional Nanomedicine for Targeted Atherosclerosis Therapy: Activating Plaque Clearance Cascade and Suppressing Inflammation.
ACS Nano
January 2025
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China.
Article Synopsis
- Atherosclerosis (AS) is an inflammatory vascular disease marked by plaque buildup, primarily made up of lipid-filled foam cells, which are hard to clear because of CD47 overexpression that hinders immune cell function.
- A new nanomedicine called CEZP targets AS treatment by enhancing macrophage activity and lipid breakdown through a combination of poly(lactic--glycolic acid) nanoparticles and metal-organic frameworks containing zinc ions and epigallocatechin gallate (EGCG).
- CEZP shows promise in stabilizing plaques, reducing lipid levels, and safely promoting cholesterol removal, presenting a low-toxicity, nonsurgical approach to treat atherosclerosis.
In Silico Analysis Revealed Marco (SR-A6) and Abca1/2 as Potential Regulators of Lipid Metabolism in M1 Macrophage Hysteresis.
Int J Mol Sci
December 2024
Department of Computational Biology and Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.
Macrophages undergo polarization, resulting in distinct phenotypes. These transitions, including de-/repolarization, lead to hysteresis, where cells retain genetic and epigenetic signatures of previous states, influencing macrophage function. We previously identified a set of interferon-stimulated genes (ISGs) associated with high lipid levels in macrophages that exhibited hysteresis following M1 polarization, suggesting potential alterations in lipid metabolism.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!