Effects of melatonin on the blood oxygen-carrying function and prooxidant - antioxidant balance in the organism were studied 12 h after lipopolysaccharide injection in rabbits. The treatment with melatonin (intraperitoneally in a dose of 4 mg/kg) before endotoxic lipopolysaccharide injection (intravenously 500 microg/kg) improved oxygen transport function of the blood, increased the hemoglobin-oxygen affinity, decreased nitrates/nitrites level, reduced the gain of free-radical processes, and increased the level of antioxidant protection factors in test animals. It is concluded that melatonin modulates the blood oxygen-carrying function and prooxidant - antioxidant balance through NO-dependent mechanisms, thus reducing the negative action of endotoxin on the organism.
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