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Departamento de Endocrinologia, Universidade Federal de São Paulo, SP, Brasil.
Published: March 2010
AI Article Synopsis
- Osteoporosis is a bone disease marked by low bone mass and deterioration, leading to an increased fracture risk from an imbalance in bone resorption and formation.
- Bisphosphonates are medications that help reduce bone loss by inhibiting osteoclast activity, thus balancing bone resorption and formation, and are available in both oral and intravenous forms.
- These medications are generally well tolerated, have a good safety profile with rare serious side effects, and are the most commonly prescribed treatment for osteoporosis.
Article Abstract
Osteoporosis is a disease characterized by low bone mass associated with the deterioration of microarchitecture, due to an imbalance either in high bone resorption or low bone formation or in both, leading to a high risk of fractures. Bisphosphonates are medications which reduce the ability of osteoclasts to induce bone resorption and consequently improve the balance between resorption and formation. There are bisphosphonates approved for the prevention and treatment of osteoporosis. Administration can be oral (daily, weekly or monthly) or intravenous (quarterly or yearly). These medications are well tolerated and with the correct instructions of administration have a good safety profile. Serious side effects, such as, osteonecrosis of jaw is very rare. Bisphosphonates are the most prescribed medication for the treatment of osteoporosis.
