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We provide an overview of the isotopic signatures of presolar supernova grains, specifically focusing on Ti-containing grains with robustly inferred supernova origins and their implications for nucleosynthesis and mixing mechanisms in supernovae. Recent technique advancements have enabled the differentiation between radiogenic (from Ti decay) and nonradiogenic Ca excesses in presolar grains, made possible by enhanced spatial resolution of Ca-Ti isotope analyses with the Cameca NanoSIMS (Nano-scale Secondary Ion Mass Spectrometer) instrument. Within the context of presolar supernova grain data, we discuss () the production of Ti in supernovae and the impact of interstellar medium heterogeneities on the galactic chemical evolution of Ca/Ca, () the nucleosynthesis processes of neutron bursts and explosive H-burning in Type II supernovae, and () challenges in identifying the progenitor supernovae for Cr-rich presolar nanospinel grains.

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Massive stars are a major source of chemical elements in the cosmos, ejecting freshly produced nuclei through winds and core-collapse supernova explosions into the interstellar medium. Among the material ejected, long-lived radioisotopes, such as Fe (iron) and Al (aluminum), offer unique signs of active nucleosynthesis in our galaxy. There is a long-standing discrepancy between the observed Fe/Al ratio by γ-ray telescopes and predictions from supernova models.

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