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Evaluation of HMGB1 Expression as a Clinical Biomarker for Cholangiocarcinoma.
Cancer Genomics Proteomics
December 2024
Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand;
Background/aim: Cholangiocarcinoma (CCA) is an epithelial malignancy that is most prevalent in Southeast Asia, particularly in the northeast of Thailand. Identifying and establishing specific biomarkers of CCA is crucial for ensuring accurate prognosis and enabling effective treatment. High-mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) molecule that can be released by dead or injured cells and is associated with tumor progression.
View Article and Find Full Text PDFAssociation between serum endocan levels and organ failure in hospitalized patients with cirrhosis.
PLoS One
December 2024
Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Background & Aims: Acute-on-chronic liver failure is a syndrome characterized by organ failure and high short-term mortality. The lack of reliable biomarkers for the early detection of acute-on-chronic liver failure is a significant challenge. Endothelial dysfunction plays a key role in the development of organ failure.
View Article and Find Full Text PDFOptimal site for applying transcutaneous bilirubinometer as an outpatient screening tool for neonatal jaundice: a comparison between the sternum and forehead.
Front Pediatr
December 2024
Department of Pediatrics, Division of Neonatology, Medical College of Wisconsin, Wauwatosa, WI, United States.
Background: The gold standard for assessing neonatal jaundice (NJ) is the serum total serum bilirubin (TSB) level by the diazo method. A transcutaneous bilirubinometer (TCB) provides a convenient, noninvasive readout within minutes. The reliability of TCB as the diagnostic tool and the proper site for TCB measurement remains unsettled.
View Article and Find Full Text PDFEvaluation of hepatoprotective and nephroprotective activities of extract in rats.
Biomed Rep
February 2025
Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, West Java 41361, Indonesia.
The liver and kidneys are important organs for body homeostasis but susceptible to damage or injury caused by different factors. A number of medicinal plants, such as have been proven effective in protecting the liver and kidneys from damage. Therefore, the present study aimed to examine the effect of extract (CcE) on paracetamol-induced hepatotoxicity and gentamicin-induced nephrotoxicity in rat model.
View Article and Find Full Text PDFDifferences in severity of reticulo-rumen pH drop in primiparous Holstein cows fed the same diet during transition and early lactation: effects on performance, energy balance, blood metabolites, and reproduction.
J Anim Sci
December 2024
Centre for Animal Nutrition and Welfare, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.
We recently reported factors leading to different severity of ruminal pH drop in primiparous cows fed the same diet during transition and early lactation. The present study evaluates the effects of those severities on performance and several blood and balance parameters in the same 24 primiparous cows from 3 wk before calving until wk 10 in lactation. Dietary concentrate was increased for all cows from 32 before calving to 60% (DM basis) over the first wk in lactation, resulting in a diet with 40% non-fiber carbohydrates (NFC), and 14.
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