The author presents case reports of two patients with musculoskeletal infection treated in the beginning by complex reconstruction operations which have finally ended up with the amputation of the extremity with a good functional and subjective result. The author deals in details with the problems of differentiated indication of various methods of treatment depending on the condition of the bone, soft tissues as well as the general condition of the patient mainly with regard to the both general and local immunity response and on technical and personnel possibilities of the clinic or hospital. Key words: musculoskeletal infection, reconstruction operations, amputation.
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