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A Toluene-induced Infundibulo-neuro-hypophysitis: Presentation of a New Cause of Hypophysitis Secondary to Toxic Exposure and Review on Toluene Inhalation Endocrine Effects.
Endocr Metab Immune Disord Drug Targets
September 2024
Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.
Article Synopsis
- Hypophysitis is a rare inflammation of the pituitary gland with varied symptoms that can make diagnosis difficult.
- A 59-year-old man developed arginine vasopressin deficiency after inhaling toluene and was effectively treated with desmopressin and corticosteroids.
- This case is notable as the first documented instance of infundibulo-neurohypophysitis caused by toluene exposure, highlighting the need for more research on toxic substances that lead to similar endocrine issues.
Deciphering the Presentation and Etiologies of Hypophysitis Highlights the Need for Repeated Systematical Investigation.
J Clin Endocrinol Metab
September 2024
Aix Marseille Université, MMG, INSERM U1251, Marmara Institute, Assistance Publique Hôpitaux de Marseille (AP-HM), Hôpital de la Conception, CRMR HYPO, Marseille, France.
Aims: Hypophysitis is defined as an inflammation of the pituitary gland and/or infundibulum. Our aim was to characterize the initial course and evolution of patients with hypophysitis according to the different etiologies.
Patients And Methods: Retrospective observational study conducted in a universitary referral hospital center.
Acquired isolated ACTH deficiency co-occurrence with breast cancer irrespective of paraneoplastic syndrome: coincidence or inevitability.
Endocrinol Diabetes Metab Case Rep
July 2024
Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Article Synopsis
- A 52-year-old woman with breast cancer experienced fatigue and was found to have isolated adrenocorticotropic hormone (ACTH) deficiency (IAD), but her pituitary gland appeared normal.
- Although there was initial suspicion of paraneoplastic IAD related to her cancer, tests showed no signs of ectopic ACTH in her tumor tissue, leading to a diagnosis of idiopathic acquired IAD instead.
- The case highlights the complexity of diagnosing IAD in cancer patients, as symptoms overlap with those of malignancies, and not all patients with IAD and cancer will develop paraneoplastic syndrome.
Isolated hypoprolactinemia: The rarest of the rare?
Rev Endocr Metab Disord
December 2024
School of Medicine, Department of Pathology, Johns Hopkins Hospital, Ross building - Room 656, 720 Rutland Avenue, Baltimore, MD, USA.
Isolated hypoprolactinemia (IHP) can be defined as the presence of consistently low serum levels of prolactin in the absence of other anterior pituitary hormone abnormalities. It is an extremely rare condition, and consequently incompletely understood and unrecognized. A recent study has reported the first cases of IHP caused by mutation in the PRL gene.
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