Aim: To specify an association between reduced renal function and atrial fibrillation (AF) in patients with chronic heart failure (CHF).
Subjects And Methods: Three hundred and forty patients (200 males and 140 females, mean age 58 +/- 13 years) with CHF were examined. The causes of CHF were arterial hypertension in 44 (13%) patients, coronary heart disease (CHD) in 112 (33%), and their concomitance in 184 (54%). Sixty-six (19%) patients had diabetes mellitus and 180 (53%) had sustained myocardial infarction. Glomerular filtration rate (GFR) was calculated using the MDRD (Modification of Diet in Renal Disease) formula. Thirty patients presented with paroxysmal persistent AF and 27 had continuous AF.
Results: GFR was 68.8 +/- 20.9 ml/min/1.73 m2 (19.2 to 149.7 ml/min/1.73 m2), 114 (33.5%) patients having a GFR of < 60 ml/min/1.73 m2. Proteinuria was observed in 38 (11.2%) patients. GFR was lower in patients with CHF and AF (58.8 +/- 14.2 ml/min/1.73 m2 than that in those without AF (69.1 +/- 18.8 ml/min/1.73 m2; p < 0.001). The patients with decreased renal function had a larger diameter of the left atrium and more commonly mitral regurgitation. Logistic regression analysis revealed that chronic renal disease (CRD) (relative risk (RR) 2.3, 95% confidence interval (CI) 1.2 to 4.3), functional class CHF (RR, 1.8, 95% CI 1.0 to 3.1) were independently associated with AF.
Conclusion: Decreased renal function predisposes to the development of AF in patients CHF. CRD should be considered as a condition presenting a risk for AF.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Prognostic significance of peripheral blood biomarkers in patients with advanced renal cell carcinoma treated with nivolumab and ipilimumab-a polish multicenter, observational study.
Clin Exp Med
January 2025
Department of Clinical Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Krakow Branch, Poland.
Immune checkpoint inhibitors have improved the treatment of metastatic renal cell carcinoma (RCC), with the combination of nivolumab (NIVO) and ipilimumab (IPI) showing promising results. However, not all patients benefit from these therapies, emphasizing the need for reliable, easily assessable biomarkers. This multicenter study involved 116 advanced RCC patients treated with NIVO + IPI across nine oncology centers in Poland.
View Article and Find Full Text PDFSuccessful use of avacopan in a case of ANCA-associated vasculitis with treatment-resistant medium-sized vessel involvement.
CEN Case Rep
January 2025
Department of Nephrology and Dialysis, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakae-Cho, Itabashi, Tokyo, 173-0015, Japan.
We report the case of a 75-year-old woman who presented with fever, right back pain, paresthesia in the right extremities, erythema, purpura, and nodules. She had previously initiated dialysis due to rapidly progressive glomerulonephritis and was transferred to our hospital. Imaging studies revealed multiple cerebral and splenic infarcts and hemorrhage encapsulating the right kidney, likely due to microaneurysms in multiple renal arteries.
View Article and Find Full Text PDFCT angiography of acute aortic syndrome in patients with chronic kidney disease.
Int J Cardiovasc Imaging
January 2025
Department of Clinical Radiology, AHEPA University Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece.
The term acute aortic syndrome (AAS) refers to a range of different entities, including dissection, intramural haematoma and penetrating atherosclerotic ulcer. Patients with chronic renal disease and particularly those with dominant polycystic kidney disease are susceptible to this pathology, given the underlying renal arteriopathy and hypertension. Imaging plays a crucial role in diagnosing, grading and guiding management of these patients, with computed tomography angiography (CTA) being on the frontline.
View Article and Find Full Text PDFPropagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson's disease.
Nat Neurosci
January 2025
Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
The pathogenesis of Lewy body diseases (LBDs), including Parkinson's disease (PD), involves α-synuclein (α-Syn) aggregation that originates in peripheral organs and spreads to the brain. PD incidence is increased in individuals with chronic renal failure, but the underlying mechanisms remain unknown. Here we observed α-Syn deposits in the kidneys of patients with LBDs and in the kidney and central nervous system of individuals with end-stage renal disease without documented LBDs.
View Article and Find Full Text PDFLymphocyte-C-reactive protein ratio upon admission to predict disease progression and ICU admission in adult patients with diabetic ketoacidosis.
Sci Rep
January 2025
Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China.
This study aimed to investigate whether lymphocyte-C-reactive protein ratio (LCR) upon admission can predict disease progression and intensive care unit (ICU) admission in adult patients with diabetic ketoacidosis (DKA). A single-center retrospective study was conducted, including adult DKA patients admitted to the First Affiliated Hospital of Harbin Medical University between March 2018 and March 2023. Multiple demographic and clinical data were collected from the medical records upon admission and during hospitalization.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!