AI Article Synopsis
- Researchers discovered three new alkaloids from the bark of Guatteria hispida, naming them 9-methoxy-O-methylmoschatoline, 9-methoxyisomoschatoline, and isocerasonine.
- In addition to the new compounds, they identified 10 known alkaloids, such as 8-oxopseudopalmatine and O-methylmoschatoline.
- Key compounds demonstrated strong antioxidant properties and some showed antimicrobial activity against specific bacteria, with minimal inhibitory concentrations ranging from 12.5 to 100 microg mL(-1).
Article Abstract
Phytochemical investigation of the bark of Guatteria hispida afforded three new alkaloids, 9-methoxy-O-methylmoschatoline (1), 9-methoxyisomoschatoline (2), and isocerasonine (3), along with 10 known alkaloids, 8-oxopseudopalmatine (4), O-methylmoschatoline (5), lysicamine (6), liriodenine (7), 10-methoxyliriodenine (8), nornuciferine (9), anonaine (10), xylopine (11), coreximine (12), and isocoreximine (13). The major compounds, 2, 6, 12, and 13, showed significant antioxidant capacity in the ORAC(FL) assay. Compounds 5, 6, and 7 were active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1).
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| http://dx.doi.org/10.1021/np100013r | DOI Listing |
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