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CT-based body composition analysis and pulmonary fat attenuation volume as biomarkers to predict overall survival in patients with non-specific interstitial pneumonia.
Eur Radiol Exp
October 2024
Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
Background: Non-specific interstitial pneumonia (NSIP) is an interstitial lung disease that can result in end-stage fibrosis. We investigated the influence of body composition and pulmonary fat attenuation volume (CTpfav) on overall survival (OS) in NSIP patients.
Methods: In this retrospective single-center study, 71 NSIP patients with a median age of 65 years (interquartile range 21.
Comparative analysis of dental pulp stem cells and stem cells from human exfoliated teeth in terms of growth kinetics, immunophenotype, self-renewal and multi lineage differentiation potential for future perspective of calcified tissue regeneration.
Pak J Med Sci
January 2022
Dr. Tashfeen Ahmad, FCPS, Ph.D. Departments of Surgery and Biological & Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
Background And Objectives: Owing to high proliferation rate, multipotency and self-renewal capability, dental pulp stem cells (DPSC) and stem cells from human exfoliated teeth (SHED) have become stem cell source of choice for cell based regenerative therapies. We aimed to compare DPSC and SHED as stem cell sources with a future use in regeneration of calcified tissue.
Methods: Explant derived human DPSC (n=9) and SHED (n=1) were cryopreserved, thawed and expanded for analysis of population doubling time, colony forming unit assay and efficiency.
Thy-1 (CD90) promotes bone formation and protects against obesity.
Sci Transl Med
August 2018
Department of Dermatology, Venereology and Allergology of Medical Faculty of Leipzig University, 04103 Leipzig, Germany.
Osteoporosis and obesity result from disturbed osteogenic and adipogenic differentiation and present emerging challenges for our aging society. Because of the regulatory role of Thy-1 in mesenchyme-derived fibroblasts, we investigated the impact of Thy-1 expression on mesenchymal stem cell (MSC) fate between osteogenic and adipogenic differentiation and consequences for bone formation and adipose tissue development in vivo. MSCs from Thy-1-deficient mice have decreased osteoblast differentiation and increased adipogenic differentiation compared to MSCs from wild-type mice.
View Article and Find Full Text PDFEnergy Excess, Glucose Utilization, and Skeletal Remodeling: New Insights.
J Bone Miner Res
August 2015
Center for Clinical & Translational Research, Maine Medical Center Research Institute, Scarborough, ME, USA.
Skeletal complications have recently been recognized as another of the several comorbidities associated with diabetes. Clinical studies suggest that disordered glucose and lipid metabolism have a profound effect on bone. Diabetes-related changes in skeletal homeostasis result in a significant increased risk of fractures, although the pathophysiology may differ from postmenopausal osteoporosis.
View Article and Find Full Text PDFCharacterization, prophylaxis, and treatment of infectious complications in craniomaxillofacial and upper extremity allotransplantation: a multicenter perspective.
Plast Reconstr Surg
April 2014
Baltimore, Md.; Pittsburgh, Pa.; and Boston, Mass. From the Department of Plastic and Reconstructive Surgery and the Division of Infectious Disease, Department of Medicine, The Johns Hopkins Hospital; the Department of Pharmacy and Therapeutics, University of Pittsburgh Medical Center; and the Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School.
Background: Vascularized composite allotransplants consist of heterogeneous tissues from different germ layers, which include skin, muscle, bone, fat, nerves, and lymph nodes. The antigenic diversity of these tissues, particularly of the highly immunogenic skin component, necessitates potent immunosuppressive regimens similar to that of some solid organ transplants. Indeed, the lifelong, high-dose, multidrug immunosuppressive protocols expose vascularized composite allotransplant recipients to considerable risk of infectious, metabolic, and neoplastic sequelae.
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