AI Article Synopsis
- Cases of total fertilization failure (TFF) can lead to canceled IVF cycles, with few available solutions.
- An infertile couple failed to conceive after multiple IVF and ICSI attempts, despite normal sperm morphology and functional tests.
- The investigation revealed cytoplasmic defects in the oocytes as the main issue, but using the husband's sperm in donor oocytes successfully led to the birth of healthy twins, suggesting a potential strategy for other couples facing TFF.
Article Abstract
Despite the advent of ICSI, cases of total fertilization failure (TFF) often lead to cycle cancellation with limited diagnostic and therapeutic strategies currently available. We report on the case of an infertile couple who failed to conceive after repeated IVF and ICSI. Sperm of the husband were morphologically normal and passed a functional test assessing their ability to activate mouse oocytes. Whether oocytes were activated artificially with calcium ionophore after injection of husband's or with donor sperm, all oocytes failed to fertilize. Multiple polar bodies and two disorganized spindle structures were predominantly observed, pointing towards a cytoplasmic defect in the oocytes as the primary cause of the couple's infertility. In fact, injection of husband's sperm into donor oocytes resulted in the delivery of healthy twins. This report describes a course of action that may be applied for couples with TFF after both IVF and ICSI.
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| http://dx.doi.org/10.1093/humrep/deq064 | DOI Listing |
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